ArticleMalaria journal2013
Performance of two rapid diagnostic tests for malaria diagnosis at the China-Myanmar border area.
Article in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries.The Cochrane database of systematic reviews · 2020Pooled it
- Summary of discordant results between rapid diagnosis tests, microscopy, and polymerase chain reaction for detecting Plasmodium mixed infection: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries.The Cochrane database of systematic reviews · 2014Pooled it
- Antimicrobial Stewardship in Tropical Infectious Diseases: Focusing on Dengue and Malaria.Tropical medicine and infectious disease · 2022Review
- Malaria diagnostic methods with the elimination goal in view.Parasitology research · 2022Review
- Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion.The Journal of infectious diseases · 2020Article
- Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar.Parasites & vectors · 2019Article
- New strains of Japanese encephalitis virus circulating in Shanghai, China after a ten-year hiatus in local mosquito surveillance.Parasites & vectors · 2019Article
- Evaluation of the Clinical Proficiency of RDTs, Microscopy and Nested PCR in the Diagnosis of Symptomatic Malaria in Ilorin, North-Central, Nigeria.Open access Macedonian journal of medical sciences · 2018Article
- Genetic diversity of Plasmodium falciparum populations in southeast and western Myanmar.Parasites & vectors · 2017Article
- Comparison of methods for detecting asymptomatic malaria infections in the China-Myanmar border area.Malaria journal · 2017Article
- Evaluation of the Parasight Platform for Malaria Diagnosis.Journal of clinical microbiology · 2017Article
- Plasmodium malariae and Plasmodium ovale infections in the China-Myanmar border area.Malaria journal · 2016Article
- Impact of interventions on malaria in internally displaced persons along the China-Myanmar border: 2011-2014.Malaria journal · 2016Article
- Computer-vision-based technology for fast, accurate and cost effective diagnosis of malaria.Malaria journal · 2015Article
- Genetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border area.Acta tropica · 2015Article
- Population dynamics and community structure of Anopheles mosquitoes along the China-Myanmar border.Parasites & vectors · 2015Article
- Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases.Scientific reports · 2015Article
- Nested PCR detection of malaria directly using blood filter paper samples from epidemiological surveys.Malaria journal · 2014Article
- Congenital malaria in China.PLoS neglected tropical diseases · 2014Review
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundRapid diagnostic tests (RDTs) have become an essential tool in the contemporary malaria control and management programmes in the world. This study aims to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area.
methodsA total 606 febrile patients in the China-Myanmar border were recruited to this study and were diagnosed for malaria infections by microscopy, two RDTs tests (Pf/Pan device, and Pv/Pf device) and nested PCR.
resultsMalaria parasites were found in 143 patients by microscopy, of which 51, 73, and 19 were Plasmodium falciparum, Plasmodium vivax and P. falciparum/P. vivax mixed infections, respectively. Compared to microscopy, the sensitivity of the Pf/Pan device was 88.6% for P. falciparum and 69.9% for P. vivax with the specificity of 90.4%. For a subset of 350 patients, the sensitivity of the Pf/Pan device and Pv/Pf device for detection of P. falciparum was 87.5% and 91.7%, respectively; and for detection of P. vivax was 72.0% and 73.8%, respectively. The specificity of the Pf/Pan device and Pv/Pf device was 94.3% and 96.5%, respectively. Nested PCR detected malaria parasites in 174 of 606 samples, of which 67, 79, two and 26 were P. falciparum, P. vivax, P. ovale and P. falciparum/P. vivax mixed infections, respectively. Compared to nested PCR, all other methods had sensitivity below 80%, suggesting that a significant number of cases were missed.
conclusionsCompared to PCR, both microscopy and RDTs had lower sensitivities. RDTs had similar performance to microscopy for P. falciparum diagnosis, but performed worse for P. vivax diagnosis. Other RDT products should be selected with higher sensitivity (and good specificity) for both P. falciparum and P. vivax diagnosis.
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