ArticleBMC cardiovascular disorders2013
Gender differences in the association of visceral and subcutaneous adiposity with adiponectin in African Americans: the Jackson Heart Study.
Article in BMC cardiovascular disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 78 citations in OpenAlex.
- Adiponectin and 8-epi-PGFThe British journal of nutrition · 2022Trial
- Review
- Inverse association of insulin-like growth factor binding protein 1 with epicardial and intrathoracic adiposity in older adults: The Longenity study.Diabetes research and clinical practice · 2026Article
- Adipokine networks in diabetic kidney disease: mechanistic insights and therapeutic implications.Lipids in health and disease · 2026Review
- Quantification of the renal sinus fat and exploration of its relationship with ectopic fat deposition in normal subjects using MRI fat fraction mapping.Frontiers in endocrinology · 2023Article
- Serum levels and gestational curve of adiponectin and leptin during adolescent pregnancy.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective.Therapeutic advances in endocrinology and metabolism · 2023Review
- The negative association of lower body fat mass with cardiometabolic disease risk factors is partially mediated by adiponectin.Endocrine connections · 2022Article
- The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism.American journal of preventive medicine · 2022Article
- Association between body composition and blood pressure in normal-weight Chinese children and adolescents.BMC pediatrics · 2022Article
- Association between MRI-based visceral adipose tissues and metabolic abnormality in a Chinese population: a cross-sectional study.Nutrition & metabolism · 2022Article
- An association between visceral or subcutaneous fat accumulation and diabetes mellitus among Japanese subjects.Diabetology & metabolic syndrome · 2021Article
- Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- Article
- Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?International journal of molecular sciences · 2020Review
- Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population.Biology of sex differences · 2020Article
- Sex Differences in Adipose Tissue Function.Endocrinology and metabolism clinics of North America · 2020Review
- Added values of DXA-derived visceral adipose tissue to discriminate cardiometabolic risks in pre-pubertal children.PloS one · 2020Article
- Association of Estradiol and Visceral Fat With Structural Brain Networks and Memory Performance in Adults.JAMA network open · 2019Observational
- Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk.Current hypertension reports · 2018Review
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundAdiponectin, paradoxically reduced in obesity and with lower levels in African Americans (AA), modulates several cardiometabolic risk factors. Because abdominal visceral adipose tissue (VAT), known to be reduced in AA, and subcutaneous adipose tissue (SAT) compartments may confer differential metabolic risk profiles, we investigated the associations of VAT and SAT with serum adiponectin, separately by gender, with the hypothesis that VAT is more strongly inversely associated with adiponectin than SAT.
methodsParticipants from the Jackson Heart Study, an ongoing cohort of AA (n = 2,799; 64% women; mean age, 55 ± 11 years) underwent computer tomography assessment of SAT and VAT volumes, and had stored serum specimens analyzed for adiponectin levels. These levels were examined by gender in relation to increments of VAT and SAT.
resultsCompared to women, men had significantly lower mean levels of adiponectin (3.9 ± 3.0 μg/mL vs. 6.0 ± 4.4 μg/mL; p < 0.01) and mean volume of SAT (1,721 ± 803 cm(3) vs. 2,668 ± 968 cm(3); p < 0.01) but significantly higher mean volume of VAT (884 ± 416 cm(3) vs. 801 ± 363 cm(3); p < 0.01). Among women, a one standard deviation increment in VAT was inversely associated with adiponectin (β = - 0.13; p < 0.0001) after controlling for age, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, education, pack-years of smoking and daily intake of alcohol. The statistically significant inverse association of VAT and adiponectin persisted after additionally adjusting for SAT, body mass index (BMI) and waist circumference (WC), suggesting that VAT provides significant information above and beyond BMI and WC. Among men, after the same multivariable adjustment, there was a direct association of SAT and adiponectin (β = 0.18; p = 0.002) that persisted when controlling for BMI and WC, supporting a beneficial effect of SAT. Insulin resistance mediated the association of SAT with adiponectin in women.
conclusionIn African Americans, abdominal visceral adipose tissue had an inverse association with serum adiponectin concentrations only among women. Abdominal subcutaneous adipose tissue appeared as a protective fat depot in men.
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