Evidence map›Paper›PMID 23432972›Full record

ArticleNanoscale research letters2013

Liposome: classification, preparation, and applications.

Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Soodabeh Davaran, Sang Woo Joo, Nosratollah Zarghami, Younes Hanifehpour, Mohammad Samiei, Mohammad Kouhi, Kazem Nejati-Koshki

Open access · goldAbstract read
In one paragraph

Article in Nanoscale research letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,058 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,058citing papers in PubMed, 2 pooled it
44.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,058 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3,457 citations in OpenAlex.

  1. Pooled it
  2. Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2025
    Pooled it
  3. Trial
  4. Reduction of Ultraviolet- and Heat-Induced Aging Using Betulin-Loaded Arginine-Caprylate Self-Assembly: Randomized Double-Blind Clinical Trials.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Trial
  5. Article
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  10. Article
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  12. [Oral mucosal administration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  13. Article
  14. Review
  15. Article
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  17. Structural Features of a Tiny Viral Protein, ORF7b of SARS-CoV-2.International journal of molecular sciences · 2026
    Article
  18. Review
  19. Review
  20. Review

998 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Abolfazl AkbarzadehDepartment of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz 51664, Iran. akbarzadehab@tbzmed.ac.ir.
Rogaie Rezaei-Sadabady
Soodabeh Davaran
Sang Woo Joo
Nosratollah Zarghami
Younes Hanifehpour
Mohammad Samiei
Mohammad Kouhi
Kazem Nejati-Koshki
Tabriz University of Medical Sciences · IRYeungnam University · KRIslamic Azad University of Tabriz · IRIslamic Azad University, Science and Research Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Since then, liposomes have made their way to the market. Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to 'second-generation liposomes', in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.

Identifiers

PMID23432972
PMCPMC3599573
OpenAlexW2097603366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.