ArticleDiagnostic pathology2013
Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- The Role of Telomerase in Breast Cancer's Response to Therapy.International journal of molecular sciences · 2022Review
- The Anticancer Efficacy of Platinum Azidothymidin on Hepatocellular Carcinoma Via Affecting the Telomerase and the BcL-2 Genes Expression.Journal of gastrointestinal cancer · 2020Article
- Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells.International journal of molecular sciences · 2019Review
- The Clinicopathological Correlations of hTERC Amplification with Esophageal Squamous Cell Precursor Lesions.Digestive diseases and sciences · 2019Article
- MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia.Annals of hematology · 2018Article
- PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma.Molecular and clinical oncology · 2016Article
- Telomere and Telomerase Therapeutics in Cancer.Genes · 2016Review
- Impact of mitochondrial telomerase over-expression on drug resistance of hepatocellular carcinoma.American journal of translational research · 2015Article
- Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells.Journal of Cancer · 2015Article
- Telomerase and hTERT: can they serve as markers for gastric cancer diagnosis?World journal of gastroenterology · 2014Article
- Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance.Diagnostic pathology · 2014Article
- Article
- The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer.Diagnostic pathology · 2013Article
- RTEL1 tagging SNPs and haplotypes were associated with glioma development.Diagnostic pathology · 2013Article
- Correlation between chemosensitivity to anticancer drugs and Bcl-2 expression in gastric cancer.International journal of clinical and experimental pathology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe determination of sensitive chemotherapy drugs for gastric cancer (GC) is one of the greatest challenges of adjuvant therapy. Here we evaluated the chemosensitivity of GC to anticancer drugs and the telomerase reverse transcriptase (hTERT) mRNA expression, and investigated the relationship of them.
methodsThe GC cells which were collected from 68 patients with primary GC were primary cultured. The chemosensitivity of GC cells to anticancer drugs was evaluated successfully using the MTT assay for 60 cases of GC cells, and the hTERT mRNA expression was examined in 60 cases of GC tissues and corresponding normal gastric mucosa and 6 cases of chronic superficial gastritis mucosa by in situ hybridization.
resultsTaxol, cisplatin and 5-fluorouracil were in general more effective than adriamycin and mitomycin for GC cells, and the chemosensitivity to anticancer drugs was associated with tumor histological types and a worse tumor grade. Compared to normal gastric mucosa tissues, hTERT mRNA expression was significantly increased in GC (P<0.05), which was related with a worse differentiation and drug-resistance to 5-fluorouracil or adriamycin in GC.
conclusionsThese data demonstrate for the first time that examinations of hTERT mRNA expression as an important factor could be used to select the chemotherapeutic drugs for GC patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1793217009875483.
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