ArticleJournal of the International Society of Sports Nutrition2013
Effect of folic acid supplementation on homocysteine concentration and association with training in handball players.
Article in Journal of the International Society of Sports Nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of four-week lasting aerobic treadmill training on hepatic injury biomarkers, oxidative stress parameters, metabolic enzymes activities and histological characteristics in liver tissue of hyperhomocysteinemic rats.Molecular and cellular biochemistry · 2025Article
- Assessment of Micro- and Macronutrient Intake in Male Competitive Athletes Using the Epic-Norfolk Food Frequency Questionnaire.Life (Basel, Switzerland) · 2025Article
- Dietary habits and knee and shoulder injury incidence in adolescent male and female handball players: the Swedish Handball Cohort.BMJ open sport & exercise medicine · 2025Article
- Oxidative Stress and Performance after Training in Professional Soccer (European Football) Players.Antioxidants (Basel, Switzerland) · 2023Article
- The effect of aerobic vs. resistance training on plasma homocysteine in individuals with type 2 diabetes.Journal of diabetes and metabolic disorders · 2020Article
- The effect of the MTHFR C677T mutation on athletic performance and the homocysteine level of soccer players and sedentary individuals.Journal of human kinetics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStrenuous physical activity can alter the status of folic acid, a vitamin directly associated with homocysteine (Hcy); alterations in this nutrient are a risk factor for cardiovascular disease. Handball players are a population at risk for nutrient deficiency because of poor dietary habits.
objectiveThe aims of this study were to evaluate nutritional status for macronutrients and folic acid in members of a high-performance handball team, and determine the effect of a nutritional intervention with folic acid supplementation and education.
designA total of 14 high-performance handball players were monitored by recording training time, training intensity (according to three levels of residual heart rate (RHR): <60%, 60%-80% and >80%), and subjective perceived exertion (RPE) during a 4-month training period. Nutritional, laboratory and physical activity variables were recorded at baseline (Week 0), after 2 months of dietary supplementation with 200 μg folic acid (50% of the recommended daily allowance) (Week 8) and after 2 months without supplementation (Week 16). We compared training load and analyzed changes in plasma concentrations of Hcy before and after the intervention.
resultsBivariate analysis showed a significant negative correlation (P < 0.01) between Hcy and folic acid concentrations (r = -0.84) at Week 8, reflecting a significant change in Hcy concentration (P < 0.05) as a result of hyperhomocysteinemia following the accumulation of high training loads. At Week 16 we observed a significant negative correlation (P < 0.01) between Hcy concentration and training time with an RHR <60%, indicating that aerobic exercise avoided abrupt changes in Hcy and may thus reduce the risk of cardiovascular accidents in high-performance athletes.
conclusionIntegral monitoring and education are needed for practitioners of handball sports to record their folic acid status, a factor that directly affects Hcy metabolism. Folic acid supplementation may protect athletes against alterations that can lead to cardiovascular events related to exertion during competition.
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Registered trials
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