ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2013
Different biokinetics of nanomedicines linking to their toxicity; an overview.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2018Pooled it
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- Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes.Iranian journal of pharmaceutical research : IJPR · 2018Article
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- Preparation of NGF encapsulated chitosan nanoparticles and its evaluation on neuronal differentiation potentiality of canine mesenchymal stem cells.Journal of materials science. Materials in medicine · 2017Article
- Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective.International journal of nanomedicine · 2017Review
- Opportunities and obstacles to the development of nanopharmaceuticals for human use.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2016Article
- Toxicity of Nanoparticles and an Overview of Current Experimental Models.Iranian biomedical journal · 2016Review
- Artemia salina as a model organism in toxicity assessment of nanoparticles.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Enhanced oxygen transfer rate and bioprocess yield by using magnetite nanoparticles in fermentation media of erythromycin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Article
- Toxicity of nanomaterials; an undermined issue.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Article
- Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Article
- Safety concerns to application of graphene compounds in pharmacy and medicine.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Article
- Preparation, characterization and optimization of sildenafil citrate loaded PLGA nanoparticles by statistical factorial design.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of the extreme rise to the knowledge of nanotechnology in pharmaceutical sciences, there are currently limited experimental works studying the interactions between nanoparticles (NPs) and the biological system. Adjustment of size and surface area plays the main role in the reaction between NPs and cells leading to their increased entrance into cells through skin, gastrointestinal and respiratory system. Moreover, change in physicochemical reactivity of NPs causes them to interact with circulatory and cellular proteins differentially leading to the altered parameters of their biokinetics, including adsorption, distribution, translocation, transformation, and elimination. A direct relationship between the surface area, reactive oxygen species generating capability, and proinflammatory effects of NPs have been found in respiratory tract toxicity. Additionally, complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanodrugs have been well defined. Inhalation studies of some NPs have confirmed the translocation of inhaled materials to extra pulmonary organs such as central nervous system (CNS) via olfactory neurons and induction of inflammatory response. Injectable uncoated NPs have a tendency to remain on the injection site while the poly ethanol glycol (PEG)-coated NPs can be notably drained from the injection site to get as far as the lymph nodes where they accumulate. This confirms the existence of channels within the extracellular matrix for NPs to move along. Furthermore, induction of DNA strand breaks and formation of micronuclei have been recorded for exposure to some NPs such as single-walled carbon nanotubes.In the recent years, most of the studies have simply outlined better efficacy of nanodrugs, but few discussed their possible toxic reactions specially if used chronically. Therefore, we emphasize that this part of the nanoscience must not be undermined and toxicologists must be sensitive to set up suitable in vivo or in vitro toxicity models. A system for collecting data about the relationships between NPs' structure-size-efficacy-toxicity (SSET) should be specified with special regard to portal of entry and target organ.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.