ArticleImmunology2013
Salmonella Typhi OmpS1 and OmpS2 porins are potent protective immunogens with adjuvant properties.
Article in Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies.PloS one · 2013Pooled it
- Differential expression of outer membrane proteins and quinolone resistance determining region mutations can lead to ciprofloxacin resistance in Salmonella Typhi.Archives of microbiology · 2023Article
- Vibrio cholerae Porin OmpU Activates Dendritic Cells via TLR2 and the NLRP3 Inflammasome.Infection and immunity · 2023Article
- Critical role of IL-25-ILC2-IL-5 axis in the production of anti-Francisella LPS IgM by B1 B cells.PLoS pathogens · 2021Article
- Outer membrane proteins ofClinical and experimental vaccine research · 2021Article
- CD4+ and CD8+ Circulating Memory T Cells Are Crucial in the Protection Induced by Vaccination withMicroorganisms · 2021Article
- The CRISPR-Cas System Is Involved in OmpR Genetic Regulation for Outer Membrane Protein Synthesis inFrontiers in microbiology · 2021Article
- Differential functional patterns of memory CD4Vaccine · 2020Article
- Induction of Progenitor Exhausted Tissue-Resident Memory CD8Frontiers in immunology · 2020Article
- Differential Recognition ofInfection and immunity · 2019Article
- Article
- An efficient and scalable synthesis of potent TLR2 agonistic PAMRSC advances · 2018Article
- Development of a novel S. Typhi and Paratyphi A outer membrane vesicles based bivalent vaccine against enteric fever.PloS one · 2018Article
- Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells.PLoS neglected tropical diseases · 2017Article
- Vaccination withVeterinary world · 2017Article
- Article
- Outer Membrane Proteins form Specific Patterns in Antibiotic-ResistantFrontiers in microbiology · 2017Article
- Toll-like receptors: the swiss army knife of immunity and vaccine development.Clinical & translational immunology · 2016Review
- Review
- Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh.Clinical and vaccine immunology : CVI · 2014Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Salmonella enterica serovar Typhi (S. Typhi) is the causal agent of typhoid fever, a disease that primarily affects developing countries. Various antigens from this bacterium have been reported to be targets of the immune response. Recently, the S. Typhi genome has been shown to encode two porins--OmpS1 and OmpS2--which are expressed at low levels under in vitro culture conditions. In this study, we demonstrate that immunizing mice with either OmpS1 or OmpS2 induced production of specific, long-term antibody titres and conferred protection against S. Typhi challenge; in particular, OmpS1 was more immunogenic and conferred greater protective effects than OmpS2. We also found that OmpS1 is a Toll-like receptor 4 (TLR4) agonist, whereas OmpS2 is a TLR2 and TLR4 agonist. Both porins induced the production of tumour necrosis factor and interleukin-6, and OmpS2 was also able to induce interleukin-10 production. Furthermore, OmpS1 induced the over-expression of MHC II molecules in dendritic cells and OmpS2 induced the over-expression of CD40 molecules in macrophages and dendritic cells. Co-immunization of OmpS1 or OmpS2 with ovalbumin (OVA) increased anti-OVA antibody titres, the duration and isotype diversity of the OVA-specific antibody response, and the proliferation of T lymphocytes. These porins also had adjuvant effects on the antibody response when co-immunized with either the Vi capsular antigen from S. Typhi or inactivated 2009 pandemic influenza A(H1N1) virus [A(H1N1)pdm09]. Taken together, the data indicate that OmpS1 and OmpS2, despite being expressed at low levels under in vitro culture conditions, are potent protective immunogens with intrinsic adjuvant properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.