Evidence map›Paper›PMID 23432360›Full record

Trial reportJournal of internal medicine2013

Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels.

C Abbenhardt, A McTiernan, C M Alfano, M H Wener, K L Campbell, C Duggan, K E Foster-Schubert, A Kong, A T Toriola, J D Potter and 5 more

Erratum issuedOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 10 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 10 syntheses or guidelines pooled it, 136 citations in OpenAlex.

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  16. Long-Term Effects of Weight Loss and Exercise on Biomarkers Associated with Angiogenesis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

C AbbenhardtDivision of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
A McTiernan
C M Alfano
M H Wener
K L Campbell
C Duggan
K E Foster-Schubert
A Kong
A T Toriola
J D Potter
C Mason
L Xiao
G L Blackburn
C Bain
C M Ulrich
Fred Hutch Cancer Center · USUniversity of Washington · USHeidelberg University · DEHarvard University · USNational Institutes of Health · USUniversity of British Columbia · CA

Funding

Preventing obesity in low income working adultsU54CA116847 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2005 to 2010
$12.6M
Institute for Translational Health Science (KL2)KL2RR025015 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$9.3M
UIC CANCER PREVENTION &CONTROL RESEARCH TRAINING GRANTR25CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FITZGIBBON, MARIAN L. · 1992 to 2017
$8.2M
Cancer Prevention Trng-Nutrition, Exercise &GeneticsR25CA094880 · NCI · UNIVERSITY OF WASHINGTON · PI WHITE, EMILY · 2002 to 2016
$7.3M
EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENR01CA105204 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2004 to 2008
$3.3M
Hu1D10 in CLL: CLINICAL AND LABORATORY STUDIESR01CA102504 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C · 2003 to 2006
$1.2M
Effect of exercise and weight loss on adipose tissue biologyR21CA131676 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2008 to 2009
$436k
CIHRNCI NIH HHS R01 CA102504NCI NIH HHS R01 CA105204NCI NIH HHS R21 CA131676NCI NIH HHS R25 CA057699NCI NIH HHS R25 CA094880NCI NIH HHS R25 CA94880 ANCI NIH HHS U54 CA116847NCI NIH HHS U54-CA116847NCRR NIH HHS 5KL2RR025015NCRR NIH HHS KL2 RR025015
6 · The paper itself

Abstract

backgroundExcess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose-derived adiponectin and leptin levels. We investigated the effects of 12-month reduced calorie, weight loss and exercise interventions on adiponectin and leptin concentrations.

methodsOverweight/obese postmenopausal women (n = 439) were randomized as follows: (i) a reduced calorie, weight-loss diet (diet; N = 118), (ii) moderate-to-vigorous intensity aerobic exercise (exercise; N = 117), (iii) a combination of a reduced calorie, weight-loss diet and moderate-to-vigorous intensity aerobic exercise (diet + exercise; N = 117), and (iv) control (N = 87). The reduced calorie diet had a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous aerobic activity 5 days per week. Adiponectin and leptin levels were measured at baseline and after 12 months of intervention using a radioimmunoassay.

resultsAdiponectin increased by 9.5% in the diet group and 6.6% in the diet + exercise group (both P ≤ 0.0001 vs. control). Compared with controls, leptin decreased with all interventions (diet + exercise, -40.1%, P < 0.0001; diet, -27.1%, P < 0.0001; exercise, -12.7%, P = 0.005). The results were not influenced by the baseline body mass index (BMI). The degree of weight loss was inversely associated with concentrations of adiponectin (diet, P-trend = 0.0002; diet + exercise, P-trend = 0.0005) and directly associated with leptin (diet, P-trend < 0.0001; diet + exercise, P-trend < 0.0001).

conclusionWeight loss through diet or diet + exercise increased adiponectin concentrations. Leptin concentrations decreased in all of the intervention groups, but the greatest reduction occurred with diet + exercise. Weight loss and exercise exerted some beneficial effects on chronic diseases via effects on adiponectin and leptin.

Indexed as

AdiponectinAgedBody Mass IndexDiet, ReducingExerciseFemaleFollow-Up StudiesHumansLeptinMiddle AgedObesityOverweightPostmenopauseReference ValuesRisk AssessmentTime FactorsAdiponectinLeptinadiponectindiet and exercise interventionleptinrandomized controlled trial

Identifiers

PMID23432360
PMCPMC3738194
OpenAlexW2062526070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.