ArticleISRN surgery2013
A practical update of surgical management of merkel cell carcinoma of the skin.
Article in ISRN surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Merkel-cell carcinoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.ESMO open · 2024Guideline
- Merkel cell carcinoma, version 1.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014Guideline
- A 30-Year Single-Centre Series of Unknown Primary Merkel Cell Carcinoma: Management and Prognosis.Cancers · 2026Article
- Review
- The Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development.Pathogens (Basel, Switzerland) · 2023Review
- High-Frequency Ultrasound in Diagnosis and Treatment of Non-Melanoma Skin Cancer in the Head and Neck Region.Diagnostics (Basel, Switzerland) · 2023Article
- Merkel Cell Carcinoma of the External Ear: Population-Based Analysis and Survival Outcomes.Cancers · 2022Article
- Wide local excision for Merkel cell carcinoma of the lower extremity: A case report.Experimental and therapeutic medicine · 2022Article
- Immunoinformatics- and Bioinformatics-Assisted Computational Designing of a Novel Multiepitopes Vaccine Against Cancer-Causing Merkel Cell Polyomavirus.Frontiers in microbiology · 2022Article
- Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma.The oncologist · 2019Review
- Treatment of Advanced Merkel Cell Carcinoma: Current Therapeutic Options and Novel Immunotherapy Approaches.Targeted oncology · 2018Review
- Burden of Disease, Early Diagnosis, and Treatment of Merkel Cell Carcinoma in Latin America.Journal of global oncology · 2018Review
- Skin cancer management-updates on Merkel cell carcinoma.Annals of translational medicine · 2018Review
- Merkel Cell Carcinoma of the Buccal Mucosa and Lower Lip.Head and neck pathology · 2018Article
- Merkel cell carcinoma: extended lymphadenectomy and reconstruction with biosynthetic prosthesis.Journal of surgical case reports · 2018Article
- Merkel cell carcinoma masquerading as cellulitis: a case report and review of the literature.Current oncology (Toronto, Ont.) · 2018Article
- Merkel cell carcinoma: Epidemiology, pathogenesis, diagnosis and therapy.Reviews in endocrine & metabolic disorders · 2017Review
- Merkel cell carcinoma.Nature reviews. Disease primers · 2017Review
- Merkel Cell Carcinoma of the Head and Neck: Recommendations for Diagnostics and Treatment.Annals of surgical oncology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of surgeons in the treatment of Merkel cell carcinoma (MCC) of the skin is reviewed, with respect to diagnosis and treatment. Most of the data in the literature are case reports. Surgery is the mainstay of treatment. A wide local excision, with sentinel node (SLN) biopsy, is the recommended treatment of choice. If SLN is involved, nodal dissection should be performed; unless patient is unfit, then regional radiotherapy can be given. Surgeons should always refer patients for assessment of the need for adjuvant treatments. Adjuvant radiotherapy is well tolerated and effective to minimize recurrence. Adjuvant chemotherapy may be considered for selected node-positive patients, as per National Comprehensive Cancer Network guideline. Data are insufficient to assess whether adjuvant chemotherapy improves survival. Recurrent disease should be treated by complete surgical resection if possible, followed by radiotherapy and possibly chemotherapy. Generally results of multimodality treatment for recurrent disease are better than lesser treatments. Future research should focus on newer chemotherapy and molecular targeted agents in the adjuvant setting and for gross disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.