ArticleInternational journal of hypertension2013
Elevated blood pressure in the acute phase of stroke and the role of Angiotensin receptor blockers.
Article in International journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-Analysis of the Safety and Efficacy of Intensive Blood Pressure Control After Thrombectomy.Brain and behavior · 2025Pooled it
- Pooled it
- Trial
- Exploring the impact of intensive versus standard blood pressure management following post-endovascular therapy in ischemic stroke: A comparative systematic review and meta-analysis.Qatar medical journal · 2025Article
- Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Review
- Blood pressure variability and stroke: A risk marker of outcome and target for intervention.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Predicting Functional Outcome Based on Linked Data After Acute Ischemic Stroke: S-SMART Score.Translational stroke research · 2020Article
- Neutrophil to Lymphocyte Ratio Is a Therapeutic Biomarker for Spontaneous Hemorrhagic Transformation.Neurotoxicity research · 2020Article
- Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study.Molecular medicine (Cambridge, Mass.) · 2020Article
- Sleep and brain health.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- The predictive role of the neutrophil-lymphocyte ratio in the prognosis of adult patients with stroke.Chinese neurosurgical journal · 2020Review
- Hypertension and arterial stiffness.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Managing blood pressure in acute intracerebral hemorrhage.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Therapeutic effect of early intensive antihypertensive treatment on rebleeding and perihematomal edema in acute intracerebral hemorrhage.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Changes in Event-Related Potentials Underlying Coma Recovery in Patients with Large Left Hemispheric Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Blood pressure and stroke: From incidence to outcome.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Neutrophil-to-Lymphocyte Ratio in Acute Cerebral Hemorrhage: a System Review.Translational stroke research · 2019Review
- Correlations of Acute Cerebral Hemorrhage Complicated with Stress Ulcer Bleeding with Acute Physiology and Chronic Health Evaluation (APACHE) II Score, Endothelin (ET), Tumor Necrosis Factor-alpha (TNF-α), and Blood Lipids.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Sleep and blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raised blood pressure (BP) is common after stroke but its causes, effects, and management still remain uncertain. We performed a systematic review of randomized controlled trials that investigated the effects of the angiotensin receptor blockers (ARBs) administered in the acute phase (≤72 hours) of stroke on death and dependency. Trials were identified from searching three electronic databases (Medline, Cochrane Library and Web of Science Database). Three trials involving 3728 patients were included. Significant difference in BP values between treatment and placebo was found in two studies. No effect of the treatment was seen on dependency, death and vascular events at one, three or six months; the cumulative mortality and the number of vascular events at 12 months differed significantly in favour of treatment in one small trial which stopped prematurely. Evidence raises doubts over the hypothesis of a specific effect of ARBs on short- and medium-term outcomes of stroke. It is not possible to rule out that different drugs might have different effects. Further trials are desirable to clarify whether current findings are generalizable or there are subgroups of patients or different approaches to BP management for which a treatment benefit can be obtained.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.