ArticlePloS one2013
Analyses of antibacterial activity and cell compatibility of titanium coated with a Zr-C-N film.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Epithelial Biological Response to Machined Titanium vs. PVD Zirconium-Coated Titanium: An In Vitro Study.Materials (Basel, Switzerland) · 2022Article
- Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: An in vitro study.PloS one · 2018Article
- Incorporation of silver nanoparticles on the surface of orthodontic microimplants to achieve antimicrobial properties.Korean journal of orthodontics · 2017Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to verify the antibacterial performance and cell proliferation activity of zirconium (Zr)-carbon (C)-nitride (N) coatings on commercially pure titanium (Ti) with different C contents. MATERIALS AND
methodsReactive nitrogen gas (N(2)) with and without acetylene (C(2)H(2)) was activated by Zr plasma in a cathodic-arc evaporation system to deposit either a zirconium nitride (ZrN) or a Zr-C-N coating onto Ti plates. The bacterial activity of the coatings was evaluated against Staphylococcus aureus with the aid of SYTO9 nucleic acid staining and scanning electron microscopy (SEM). Cell compatibility, mRNA expression, and morphology related to human gingival fibroblasts (HGFs) on the coated samples were also determined by using the MTT assay, reverse transcriptase-polymerase chain reaction, and SEM.
resultsThe Zr-C-N coating with the highest C content (21.7 at%) exhibited the lowest bacterial preservation (P<0.001). Biological responses including proliferation, gene expression, and attachment of HGF cells to ZrN and Zr-C-N coatings were comparable to those of the uncoated Ti plate.
conclusionsHigh-C-content Zr-C-N coatings not only provide short-term antibacterial activity against S. aureus but are also biocompatible with HGF cells.
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