ArticlePLoS biology2013
Parallel evolutionary dynamics of adaptive diversification in Escherichia coli.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed, 220 citations in OpenAlex.
- Emergent frequency-dependent selection predicts mutation outcomes in complex ecological communities.bioRxiv : the preprint server for biology · 2026Article
- Experimental evolution in an era of molecular manipulation.Nature reviews. Genetics · 2026Review
- Ecological diversification in rapidly evolving populations.bioRxiv : the preprint server for biology · 2025Article
- Frequency-dependent fitness effects are ubiquitous.bioRxiv : the preprint server for biology · 2025Article
- Evolution of Escherichia coli strains under competent or compromised adaptive immunity.PLoS pathogens · 2025Article
- Detecting (the Absence of) Species Interactions in Microbial Ecological Systems.Studies in applied mathematics (Cambridge, Mass.) · 2025Article
- Experimental evolution reveals evolutionary bias and its causes.BMC ecology and evolution · 2024Article
- Competition for resources can reshape the evolutionary properties of spatial structure.PLoS computational biology · 2024Article
- Evolution of pH-sensitive transcription termination inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Patterns of Fitness and Gene Expression Epistasis Generated by Beneficial Mutations in the rho and rpoB Genes of Escherichia coli during High-Temperature Adaptation.Molecular biology and evolution · 2024Article
- Competition for resources can reshape the evolutionary properties of spatial structure.bioRxiv : the preprint server for biology · 2024Article
- Evolution of pH-sensitive transcription termination during adaptation to repeated long-term starvation.bioRxiv : the preprint server for biology · 2024Article
- Rediversification following ecotype isolation reveals hidden adaptive potential.Current biology : CB · 2024Article
- Horizontal gene transfer facilitates the molecular reverse-evolution of antibiotic sensitivity in experimental populations of H. pylori.Nature ecology & evolution · 2024Article
- Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024Article
- Timesweeper: accurately identifying selective sweeps using population genomic time series.Genetics · 2023Article
- Evolutionary repeatability of emergent properties of ecological communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Evolutionary Trajectories are Contingent on Mitonuclear Interactions.Molecular biology and evolution · 2023Article
- Article
- Genomic Legacies of Ancient Adaptation Illuminate GC-Content Evolution in Bacteria.Microbiology spectrum · 2023Article
53 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causes and mechanisms of evolutionary diversification are central issues in biology. Geographic isolation is the traditional explanation for diversification, but recent theoretical and empirical studies have shown that frequency-dependent selection can drive diversification without isolation and that adaptive diversification occurring in sympatry may be an important source of biological diversity. However, there are no empirical examples in which sympatric lineage splits have been understood at the genetic level, and it is unknown how predictable this process is-that is, whether similar ecological settings lead to parallel evolutionary dynamics of diversification. We documented the genetic basis and the evolutionary dynamics of adaptive diversification in three replicate evolution experiments, in which competition for two carbon sources caused initially isogenic populations of the bacterium Escherichia coli to diversify into two coexisting ecotypes representing different physiological adaptations in the central carbohydrate metabolism. Whole-genome sequencing of clones of each ecotype from different populations revealed many parallel and some unique genetic changes underlying the derived phenotypes, including changes to the same genes and sometimes to the same nucleotide. Timelines of allele frequencies extracted from the frozen "fossil" record of the three evolving populations suggest parallel evolutionary dynamics driven at least in part by a co-evolutionary process in which mutations causing one type of physiology changed the ecological environment, allowing the invasion of mutations causing an alternate physiology. This process closely corresponds to the evolutionary dynamics seen in mathematical models of adaptive diversification due to frequency-dependent ecological interactions. The parallel genetic changes underlying similar phenotypes in independently evolved lineages provide empirical evidence of adaptive diversification as a predictable evolutionary process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.