ArticleProceedings of the National Academy of Sciences of the United States of America2013
BIK1 interacts with PEPRs to mediate ethylene-induced immunity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.
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Who cites it
159 citing papers in PubMed, 1 synthesis or guideline pooled it, 331 citations in OpenAlex.
- Root colonization by beneficial rhizobacteria.FEMS microbiology reviews · 2024Pooled it
- Receptor-like cytoplasmic kinases VII subfamily orchestrates reactive oxygen species signaling in plant immunity.Plant signaling & behavior · 2026Review
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- NIK receptor kinases propagate phytocytokine-triggered immunity by driving early phosphorylation events.Nature plants · 2026Article
- The Plant Cell Wall: From Structural Diversity and Biosynthesis to Integrity Signaling and Physiological Functions.Plants (Basel, Switzerland) · 2026Review
- Article
- S-acylation switches the fate of a plant peptide precursor in cell wall damage responses.Science advances · 2026Article
- PEPR1 Mediates SsNLP1-Triggered Immunity AgainstInternational journal of molecular sciences · 2026Article
- Current Understanding of Cell-Surface Immune Receptors for MAMPs and Plant Parasites in the Solanaceae Family.Molecular plant pathology · 2026Review
- Two pear phytocytokines PbePep4 and PdrPep6 interfamilially elicit broad-spectrum immunity against various pathogens in crops.Horticulture research · 2026Article
- Parasitic Plant-Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Screening and Validation of Interacting Proteins of Receptor-like Cytoplasmic Kinase OsRLCK118 Involved in Rice Blast Resistance.Journal of fungi (Basel, Switzerland) · 2026Article
- New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions.Nature plants · 2026Article
- Motif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity.Nature plants · 2026Article
- Identification and functional characterization of a novel gene conferring root rot resistance in Panax Notoginseng.BMC plant biology · 2026Article
- Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- Arabidopsis thaliana Cyclic Nucleotide-Gated Channel 19 is involved in root extracellular ATP and Pep1 signalling.The New phytologist · 2025Article
- Salt Stress Mitigation and Field-Relevant Biostimulant Activity of Prosystemin Protein Fragments: Novel Tools for Cutting-Edge Solutions in Agriculture.Plants (Basel, Switzerland) · 2025Article
99 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have evolved intricate immune mechanisms to combat pathogen infection. Upon perception of pathogen-derived signals, plants accumulate defense hormones such as ethylene (ET), jasmonate, salicylate, and damage-associated molecular patterns to amplify immune responses. In particular, the Arabidopsis peptide Pep1 and its family members are thought to be damage-associated molecular patterns that trigger immunity through Pep1 receptor kinases PEPR1 and PEPR2. Here we show that PEPR1 specifically interacts with receptor-like cytoplasmic kinases botrytis-induced kinase 1 (BIK1) and PBS1-like 1 (PBL1) to mediate Pep1-induced defenses. In vitro and in vivo studies suggested that PEPR1, and likely PEPR2, directly phosphorylates BIK1 in response to Pep1 treatment. Surprisingly, the pepr1/pepr2 double-mutant seedlings displayed reduced in sensitivity to ET, as indicated by the elongated hypocotyls. ET-induced expression of defense genes and resistance to Botrytis cinerea were compromised in pepr1/pepr2 and bik1 mutants, reenforcing an important role of PEPRs and BIK1 in ET-mediated defense signaling. Pep treatment partially mimicked ET-induced seedling growth inhibition in a PEPR- and BIK1-dependent manner. Furthermore, both ET and Pep1 treatments induced BIK1 phosphorylation in a PEPR-dependent manner. However, the Pep1-induced BIK1 phosphorylation, seedling growth inhibition, and defense gene expression were independent of canonical ET signaling components. Together our results illustrate a mechanism by which ET and PEPR signaling pathways act in concert to amplify immune responses.
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