Evidence map›Paper›PMID 23431120›Full record

Trial reportWorld journal of gastroenterology2013

Effects of early enteral nutrition on immune function of severe acute pancreatitis patients.

Jia-Kui Sun, Xin-Wei Mu, Wei-Qin Li, Zhi-Hui Tong, Jing Li, Shu-Yun Zheng

Open access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 12 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 12 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
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  3. [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020
    Guideline
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  13. Effects of permissive hypocaloricWorld journal of gastroenterology · 2021
    Trial
  14. Trial
  15. Trial
  16. Cancer-Associated Cachexia in the Era of Obesity.International journal of molecular sciences · 2025
    Review
  17. Impact of protein intervention timings on critically ill patients: A systematic review and meta- analysis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jia-Kui SunDepartment of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China.
Xin-Wei Mu
Wei-Qin Li
Zhi-Hui Tong
Jing Li
Shu-Yun Zheng
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP).

methodsPatients were randomly allocated to receive EEN or delayed enteral nutrition (DEN). Enteral nutrition was started within 48 h after admission in EEN group, whereas from the 8(th) day in DEN group. All the immunologic parameters and C-reactive protein (CRP) levels were collected on days 1, 3, 7 and 14 after admission. The clinical outcome variables were also recorded.

resultsSixty SAP patients were enrolled to this study. The CD4+ T-lymphocyte percentage, CD4+/CD8+ ratio, and the CRP levels in EEN group became significantly lower than in DEN group from the 7(th) day after admission. In contrast, the immunoglobulin G (IgG) levels and human leukocyte antigen-DR expression in EEN group became significantly higher than in DEN group from the 7(th) day after admission. No difference of CD8+ T-lymphocyte percentage, IgM and IgA levels was found between the two groups. The incidences of multiple organ dysfunction syndrome, systemic inflammatory response syndrome, and pancreatic infection as well as the duration of intensive care unit stay were significantly lower in EEN group than in DEN group. However, there was no difference of hospital mortality between the two groups.

conclusionEEN moderates the excessive immune response during the early stage of SAP without leading to subsequent immunosuppression. EEN can improve the clinical outcome, but not decrease the hospital mortality of SAP patients.

Indexed as

Acute DiseaseAdultBiomarkersCD4-CD8 RatioChinaChi-Square DistributionC-Reactive ProteinEnteral NutritionFemaleHLA-DR AntigensHospital MortalityHumansImmunocompetenceImmunocompromised HostImmunoglobulin AImmunoglobulin GBiomarkersC-Reactive ProteinHLA-DR AntigensImmunoglobulin AImmunoglobulin GInflammation MediatorsEarly enteral nutritionImmuneSevere acute pancreatitis

Identifiers

PMID23431120
PMCPMC3574890
OpenAlexW2123585372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.