ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2012
Effects of chronic mild stress in female bax inhibitor-1-gene knockout mice.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optimization of Analysis of Circadian Rest-Activity Rhythm Using Cosinor Analysis in Mice.Psychiatry investigation · 2022Article
- Cellular Response to Unfolded Proteins in Depression.Life (Basel, Switzerland) · 2021Review
- Role of endoplasmic reticulum stress in depression (Review).Molecular medicine reports · 2019Review
- Article
- The characteristics of Bax inhibitor-1 and its related diseases.Current molecular medicine · 2014Review
- Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract.PloS one · 2014Article
- The protective role of Bax inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A.Scientific reports · 2013Article
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6 authors.
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Abstract
objectiveThe anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1(-/-) mice exhibit increased sensitivity to tissue damage. The purpose of this study was to investigate the role of BI-1 in the pathogenesis of chronic mild stress (CMS)-induced depression-like behaviors in BI-1(-/-) mice.
methodsWe delivered CMS for 2 or 6 weeks in BI-1-knockout and wild-type mice. Control groups of BI-1-knockout and wild-type mice were left undisturbed. The measured parameters were sucrose consumption at weeks 1, 2, 3, 4, 5, and 6, spontaneous locomotion, and a forced swimming test (FST) at weeks 2 and 6.
resultsSignificant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups. Interestingly, at week 2, but not at week 6, BI-1(-/-)-stress mice showed less sucrose intake and greater immobility time than did BI-1(+/+)-stress mice.
conclusionThese results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term. Further study is required to deepen understanding of the role of BI-1 in protecting against depression.
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