ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013
Effects of nicotine on olfactogustatory incentives: preference, palatability, and operant choice tests.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The Public Health Impacts of Flavored Cigar Bans: A Systematic Review and Meta-Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- Flavor additives facilitate oral self-administration of nicotine solution in mice.Psychopharmacology · 2021Article
- Trends and Associations of Menthol Cigarette Smoking Among US Middle and High School Students-National Youth Tobacco Survey, 2011-2018.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Nicotine Self-Administration With Tobacco Flavor Additives in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents.Drug and alcohol dependence · 2019Article
- Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat.Frontiers in behavioral neuroscience · 2019Article
- Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine.Neuropharmacology · 2017Article
- Nicotine Acutely Enhances Reinforcement from Non-Drug Rewards in Humans.Frontiers in psychiatry · 2017Review
- Association between menthol-flavoured cigarette smoking and flavoured little cigar and cigarillo use among African-American, Hispanic, and white young and middle-aged adult smokers.Tobacco control · 2016Article
- Nicotine Enhances Footshock- and Lithium Chloride-Conditioned Place Avoidance in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.Psychopharmacology · 2016Article
- Why We Must Continue to Investigate Menthol's Role in the African American Smoking Paradox.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Review
- The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.Physiology & behavior · 2016Article
- Examining the reinforcement-enhancement effects of phencyclidine and its interactions with nicotine on lever-pressing for a visual stimulus.Behavioural brain research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe use of additives in tobacco may capitalize on the incentive motivational properties of tastes and scents such as mint (menthol), vanilla, and strawberry. These incentives are intended to increase tobacco experimentation, but their salience may also be enhanced by the incentive amplifying effects of nicotine (NIC). The goal of the present studies was to investigate the potential interaction between the incentive amplifying effects of NIC and gustatory incentives.
methodsOne of two discriminable tastes (grape or cherry Kool-Aid®; 0.05% wt/vol; unsweetened) was paired with sucrose (20% wt/vol; conditioned stimulus [CS+]) in deionized water, whereas the other taste (CS-) was presented in deionized water. Experiment 1 investigated the effects of NIC pretreatment on preference for the CS+ versus CS- in 2-bottle choice tests. Experiment 2 investigated the effects of NIC on palatability of the CS+ and CS- using orofacial taste reactions. Experiment 3 investigated the effects of NIC on reinforcement by the CS+ and CS- using a concurrent choice operant task.
resultsNIC pretreatment robustly increased operant responding for the CS+ but did not alter responding for the CS- in the operant choice task (Experiment 3). However, NIC pretreatment did not alter intake or palatability of the CS+ or CS- (Experiments 1 and 2).
conclusionsNIC increases the reinforcing effects of gustatory incentive stimuli, even though these stimuli were not paired with NIC administration. The findings suggest that adding taste incentives to tobacco products may increase the attractiveness of these products to consumers and the probability of repeated use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.