ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2012
Association between low red blood cell 5-methyltetrahydrofolate and hyperhomocysteinaemia with hypertension : a cross-sectional study.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?International journal of molecular sciences · 2024Review
- Coronary Artery Disease Is Related to Methylation Disorders Caused by the c.1286A>CReports (MDPI) · 2024Article
- Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population.Scientific reports · 2017Article
- A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia.Frontiers in pharmacology · 2017Review
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2 authors at 1 institution in 1 country.
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Abstract
backgroundHyperhomocysteinaemia and other risk factors associated with blood pressure have been reported in large community-based studies in different populations. However, it is not fully established whether hypertension is associated with high plasma total homocysteine levels (tHcy) or components of the homocysteine re-methylation pathway including vitamin B(12), plasma 5-methyltetrahydrofolate (5-MTHF) or red blood cell (RBC) 5-MTHF.
aimIn this study we tested the hypothesis that RBC 5-MTHF could be a marker for long-term folate status in the blood and low RBC 5-MTHF may be associated with hypertension.
methodsThis was a cross-sectional study in a community-based setting and 492 males and 431 females were investigated. Systolic and diastolic blood pressures were determined and fasting blood samples were taken for determination of plasma tHcy, creatinine, uric acid, lipids, plasma 5-MTHF, RBC 5-MTHF and vitamin B(12).
resultsIn males, the risk of hypertension was significantly (95% CI 1.9, 8.7; p = 0.003) increased by 1.8-fold in the first quartile compared with the highest quartile of RBC 5-MTHF when adjusted for body mass index (BMI), age, dyslipidaemia, uric acid, creatinine, smoking, plasma tHcy and vitamin B(12). The risk of hypertension was also significantly increased (95% CI 1.1, 9.2; p = 0.03) by 1.1-fold in the highest quartile compared with the lowest quartile of plasma tHcy when adjusted for BMI, age, dyslipidaemia, uric acid, creatinine, smoking, plasma and RBC 5-MTHF and vitamin B(12). There were no associations of hypertension with plasma tHcy, and other components of the Hcy re-methylation pathway were observed in females.
conclusionsThe association between hypertension and low RBC 5-MTHF was stronger than any other components of the homocysteine re-methylation pathway. Results from this study suggest that folate measurements in RBC seem to be the most reliable marker indicating 5-MTHF deficiency and disturbances in the Hcy re-methylation pathway in association with hypertension.
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