ArticlePharmaceutical research2013
A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.
Article in Pharmaceutical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model.Drug delivery · 2026Article
- Primary Small Intestinal Epithelia Are Physiological Alternatives to the Caco-2 Lymphatic Transport Model.Molecular pharmaceutics · 2025Article
- Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats.Frontiers in pharmacology · 2023Article
- Targeting the Gut Mucosal Immune System Using Nanomaterials.Pharmaceutics · 2021Review
- Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity.Nature metabolism · 2021Article
- Article
- An update on oral drug deliveryActa pharmaceutica Sinica. B · 2021Review
- Lymphatic Transport of Drugs after Intestinal Absorption: Impact of Drug Formulation and Physicochemical Properties.Pharmaceutical research · 2020Article
- Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans.Frontiers in physiology · 2020Article
- Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake.Acta pharmaceutica Sinica. B · 2017Article
- Article
- From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.Nature reviews. Drug discovery · 2015Review
- Species differences in tumour responses to cancer chemotherapy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies.Pharmaceutical research · 2015Article
- The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo establish a lymph-cannulated mouse model, and use the model to investigate the impact of lipid dose on exogenous and endogenous lipid recruitment, and drug transport, into the lymph of males versus females. Finally, lymphatic transport and drug absorption in the mouse were compared to other pre-clinical models (rats/dogs).
methodsAnimals were orally or intraduodenally administered 1.6 mg/kg halofantrine in low or high (14)C-lipid doses. For bioavailability calculation, animals were intravenuosly administered halofantrine. Lymph or blood samples were taken and halofantrine, triglyceride, phospholipid and (14)C-lipid concentrations measured.
resultsLymphatic lipid transport increased linearly with lipid dose, was similar across species and in male/female animals. In contrast, lymphatic transport of halofantrine differed markedly across species (dogs>rats>mice) and plateaued at higher lipid doses. Lower bioavailability appeared responsible for some species differences in halofantrine lymphatic transport; however other systematic differences were involved.
conclusionsA contemporary lymph-cannulated mouse model was established which will enable investigation of lymphatic transport in transgenic and disease models. The current study found halofantrine absorption and lymphatic transport are reduced in small animals. Future analyses will investigate mechanisms involved, and if similar trends occur for other drugs, to establish the most relevant model(s) to predict lymphatic transport in humans.
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