ArticleThe Journal of biological chemistry2013
Variable electron transfer pathways in an amphibian cryptochrome: tryptophan versus tyrosine-based radical pairs.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Biological semiconductors: self-assembled shell proteins as photoactive materials.Chemical science · 2026Article
- FeSBCP analogue from cyanobacteria: insights from in vitro and in silico studies.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome.The FEBS journal · 2025Article
- Spectroscopic Characterization of Radical Pair Photochemistry in Nonmigratory Avian Cryptochromes: Magnetic Field Effects inJournal of the American Chemical Society · 2025Article
- Elucidation of a distinct photoreduction pathway in class IIProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Activation of Cryptochrome 4 from Atlantic Herring.Biology · 2024Article
- A structural decryption of cryptochromes.Frontiers in chemistry · 2024Review
- Article
- Tryptophan Can Promote Oxygen Reduction to Water in a Biosynthetic Model of Heme Copper Oxidases.Biochemistry · 2023Article
- A topologically distinct class of photolyases specific for UV lesions within single-stranded DNA.Nucleic acids research · 2020Article
- Regulatory Impact of the C-Terminal Tail on Charge Transfer Pathways inMolecules (Basel, Switzerland) · 2020Article
- Ultrafast flavin/tryptophan radical pair kinetics in a magnetically sensitive artificial protein.Physical chemistry chemical physics : PCCP · 2019Article
- The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster.Physical chemistry chemical physics : PCCP · 2018Article
- Proposal to use superparamagnetic nanoparticles to test the role of cryptochrome in magnetoreception.Journal of the Royal Society, Interface · 2018Article
- Molecular Insights into Variable Electron Transfer in Amphibian Cryptochrome.Biophysical journal · 2018Article
- Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional role of an unusual tyrosine residue in the electron transfer chain of a prokaryotic (6-4) photolyase.Chemical science · 2018Article
- Computational reconstruction reveals a candidate magnetic biocompass to be likely irrelevant for magnetoreception.Scientific reports · 2017Article
- Magnetic field effect in natural cryptochrome explored with model compound.Scientific reports · 2017Article
- Magnetic Fields Modulate Blue-Light-Dependent Regulation of Neuronal Firing by Cryptochrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
Electron transfer reactions play vital roles in many biological processes. Very often the transfer of charge(s) proceeds stepwise over large distances involving several amino acid residues. By using time-resolved electron paramagnetic resonance and optical spectroscopy, we have studied the mechanism of light-induced reduction of the FAD cofactor of cryptochrome/photolyase family proteins. In this study, we demonstrate that electron abstraction from a nearby amino acid by the excited FAD triggers further electron transfer steps even if the conserved chain of three tryptophans, known to be an effective electron transfer pathway in these proteins, is blocked. Furthermore, we were able to characterize this secondary electron transfer pathway and identify the amino acid partner of the resulting flavin-amino acid radical pair as a tyrosine located at the protein surface. This alternative electron transfer pathway could explain why interrupting the conserved tryptophan triad does not necessarily alter photoreactions of cryptochromes in vivo. Taken together, our results demonstrate that light-induced electron transfer is a robust property of cryptochromes and more intricate than commonly anticipated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.