ArticleThe Journal of biological chemistry2013
Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Serine proteases and protease-activated receptors signaling in the kidney.American journal of physiology. Cell physiology · 2025Review
- The Many Faces of Protease-Activated Receptor 2 in Kidney Injury.Biomedicines · 2025Review
- Soluble dipeptidyl peptidase-4 induces epithelial-mesenchymal transition through tumor growth factor-β receptor.Pharmacological reports : PR · 2023Article
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Kidney stone formation in a novel murine model of polycystic kidney disease.American journal of physiology. Renal physiology · 2022Article
- A variant of ASIC2 mediates sodium retention in nephrotic syndrome.JCI insight · 2021Article
- Time course of renal sodium transport in the pregnant rat.Current research in physiology · 2021Article
- Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.American journal of physiology. Renal physiology · 2018Article
- Dietary sodium induces a redistribution of the tubular metabolic workload.The Journal of physiology · 2017Article
- Protease-activated receptors in kidney disease progression.American journal of physiology. Renal physiology · 2016Review
- H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.Pflugers Archiv : European journal of physiology · 2016Article
- New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors.World journal of biological chemistry · 2016Review
- Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells.BMC oral health · 2015Article
- Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its extracellular N-terminal domain by trypsin and related proteases. PAR2 is expressed in kidney collecting ducts, a main site of control of Na(+) and K(+) homeostasis, but its function remains unknown. We evaluated whether and how PAR2 might control electrolyte transport in collecting ducts, and thereby participate in the regulation of blood pressure and plasma K(+) concentration. PAR2 is expressed at the basolateral border of principal and intercalated cells of the collecting duct where it inhibits K(+) secretion and stimulates Na(+) reabsorption, respectively. Invalidation of PAR2 gene impairs the ability of the kidney to control Na(+) and K(+) balance and promotes hypotension and hypokalemia in response to Na(+) and K(+) depletion, respectively. This study not only reveals a new role of proteases in the control of blood pressure and plasma potassium level, but it also identifies a second membrane receptor, after angiotensin 2 receptor, that differentially controls sodium reabsorption and potassium secretion in the late distal tubule. Conversely to angiotensin 2 receptor, PAR2 is involved in the regulation of sodium and potassium balance in the context of either stimulation or nonstimulation of the renin/angiotensin/aldosterone system. Therefore PAR2 appears not only as a new actor of the aldosterone paradox, but also as an aldosterone-independent modulator of blood pressure and plasma potassium.
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