ReviewWorld journal of gastroenterology2013
Diagnosis and management of insulinoma.
Review in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
218 citing papers in PubMed, 4 syntheses or guidelines pooled it, 464 citations in OpenAlex.
- Enucleation for insulinoma: consolidating evidence through systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- A Systematic Review of the Accuracy of Insulin and C-peptide Secretion Ratios During the Oral Glucose Tolerance Test to Diagnose Insulinoma.Journal of the ASEAN Federation of Endocrine Societies · 2024Pooled it
- Ectopic insulinoma: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors.Neuroendocrinology · 2016Guideline
- Ersodetug for refractory hypoglycemia due to malignant insulin-secreting tumors.The Journal of clinical endocrinology and metabolism · 2026Article
- 68Ga-DOTA-exendin-4 PET/CT for insulinoma localization in patients with negative or inconclusive conventional imaging.The Journal of clinical endocrinology and metabolism · 2026Article
- A 30-year institutional experience of insulinoma management at a tertiary care center: a case series.Gland surgery · 2026Article
- Occult Insulinoma: A 19-Year Diagnostic Delay in a Patient With Recurrent Hypoglycemia.Cureus · 2026Article
- Reliable localization of insulinomas with [EJNMMI research · 2026Article
- Insulinoma in a Young Patient With Focal Seizures: A Case Report of a Neurological Diagnostic Challenge.Clinical case reports · 2026Article
- Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma.PloS one · 2026Article
- DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic Target.Cellular and molecular gastroenterology and hepatology · 2026Article
- Insulinoma in pregnancy: a case report and literature review of diagnostic challenges, multidisciplinary management, and therapeutic dilemmas.Frontiers in endocrinology · 2026Review
- Illuminating the Uncinate: Advanced Indocyanine Green Fluorescence and Ultrasound-Guided Robotic Enucleation of a Pancreatic Insulinoma in a Challenging Position.Annals of surgical oncology · 2025Article
- From diagnosis to treatment: navigating the course for pancreatic neuroendocrine neoplasms.Annals of medicine · 2025Review
- Successful Endoscopic Ultrasound-Guided Radiofrequency Ablation for Symptomatic Insulinoma in a High-Risk Elderly Patient.ACG case reports journal · 2025Article
- Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review.Radiology case reports · 2025Article
- A 14-yr-old boy with a pathogenicClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2025Article
- Postoperative complications following surgery for congenital hyperinsulinism and insulinomas in pediatric patients.Pediatric surgery international · 2025Article
- Diagnosis and Surgical Management of Pancreatic Insulinoma in a Non-Diabetic Patient: A Case Report.Reports (MDPI) · 2025Article
158 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulinomas, the most common cause of hypoglycemia related to endogenous hyperinsulinism, occur in 1-4 people per million of the general population. Common autonomic symptoms of insulinoma include diaphroresis, tremor, and palpitations, whereas neuroglycopenenic symptoms include confusion, behavioural changes, personality changes, visual disturbances, seizure, and coma. Diagnosis of suspected cases is based on standard endocrine tests, especially the prolonged fasting test. Non-invasive imaging procedures, such as computed tomography and magnetic resonance imaging, are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion. Invasive modalities, such as endoscopic ultrasonography and arterial stimulation venous sampling, are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to non-invasive localization techniques. The range of techniques available for the localization of insulinomas means that blind resection can be avoided. Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas. A high proportion of patients with insulinomas can be cured with surgery. In patients with malignant insulinomas, an aggressive medical approach, including extended pancreatic resection, liver resection, liver transplantation, chemoembolization, or radiofrequency ablation, is recommended to improve both survival and quality of life. In patients with unresectable or uncontrollable insulinomas, such as malignant insulinoma of the pancreas, several techniques should be considered, including administration of ocreotide and/or continuous glucose monitoring, to prevent hypoglycemic episodes and to improve quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.