ArticleClinical journal of the American Society of Nephrology : CJASN2013
Age at graft loss after pediatric kidney transplantation: exploring the high-risk age window.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Association between transplant glomerulopathy and graft outcomes following kidney transplantation: A meta-analysis.PloS one · 2020Pooled it
- Young adults' perspectives on living with kidney failure: a systematic review and thematic synthesis of qualitative studies.BMJ open · 2018Pooled it
- Guidance from a participant advisory committee on research involving young adult kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association Between Age at Kidney Transplantation and Risk of Early Graft Loss.Pediatric transplantation · 2026Article
- Kidney Transplantation in Childhood-Onset ANCA-Associated Vasculitis: Long-Term Outcomes and Prognostic Factors.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Retrospective comparison of two distinct dual-induction strategies in pediatric kidney transplantation: three doses vs. a single dose of rabbit antithymocyte globulin, each combined with two basiliximab doses.Frontiers in pediatrics · 2026Article
- Pubertal stage specific changes in T-cell subpopulations in healthy individuals.Scientific reports · 2025Article
- Caring for Adolescents and Young Adults With Kidney Disease: Nephrologist Education.Kidney medicine · 2025Article
- Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Association between the Stanford Integrated Psychosocial Assessment for Transplant and 1-year medication nonadherence after living kidney transplantation.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Adult outcomes of childhood kidney replacement therapy in Europe from 2008 to 2019: an ERA Registry study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients.Frontiers in transplantation · 2025Article
- Transition of care from pediatric to adult nephrology post-renal transplant: a review.Translational pediatrics · 2024Review
- An integrated machine learning model enhances delayed graft function prediction in pediatric renal transplantation from deceased donors.BMC medicine · 2024Article
- Long-Term Graft and Patient Survival After Re-Transplantation.Annals of transplantation · 2024Article
- Strategies for choosing the best living donor: A review of the literature and a proposal of a decision-making paradigm.Pediatric transplantation · 2024Review
- Role of primary care in enhancing continuity of care for adolescents and young adults with chronic kidney disease undergoing transition to adult health services.Pediatric nephrology (Berlin, Germany) · 2024Article
- Contraception in Medically Complex Adolescents and Young Adults.Open access journal of contraception · 2024Article
- Transition of Care in Children with Chronic Kidney Disease, Dialysis, and Transplantation.Indian journal of pediatrics · 2023Review
- Long term outcomes following kidney transplantation in children who weighed less than 15 kg - report from the UK Transplant Registry.Pediatric nephrology (Berlin, Germany) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe risk of graft loss after pediatric kidney transplantation increases during late adolescence and early adulthood, but the extent to which this phenomenon affects all recipients is unknown. This study explored interactions between recipient factors and this high-risk age window, searching for a recipient phenotype that may be less susceptible during this detrimental age interval. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: With use of Scientific Registry of Transplant Recipients data from 1987 to 2010, risk of graft loss across recipient age was quantified using a multivariable piecewise-constant hazard rate model with time-varying coefficients for recipient risk factors.
resultsAmong 16,266 recipients, graft loss during ages ≥17 and <24 years was greater than that for both 3-17 years (adjusted hazard ratio [aHR], 1.61; P<0.001) and ≥24 years (aHR, 1.28; P<0.001). This finding was consistent across age at transplantation, sex, race, cause of renal disease, insurance type, pretransplant dialysis history, previous transplant, peak panel-reactive antibody (PRA), and type of induction immunosuppression. The high-risk window was seen in both living-donor and deceased-donor transplant recipients, at all levels of HLA mismatch, regardless of centers' pediatric transplant volume, and consistently over time. The relationship between graft loss risk and donor type, PRA, transplant history, insurance type, and cause of renal disease was diminished upon entry into the high-risk window.
conclusionsNo recipient subgroups are exempt from the dramatic increase in graft loss during late adolescence and early adulthood, a high-risk window that modifies the relationship between typical recipient risk factors and graft loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.