ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2013
Legionella prevention in the Netherlands: an evaluation using genotype distribution.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Outbreak of Legionnaires' Disease Linked to Newly Installed Residential Water Heaters, the Netherlands, 2022-2023.Emerging infectious diseases · 2026Review
- A Tale of Four Danish Cities:International journal of environmental research and public health · 2022Article
- Legionella pneumophila and Other Legionella Species Isolated from Legionellosis Patients in Japan between 2008 and 2016.Applied and environmental microbiology · 2018Article
- Genomic heterogeneity differentiates clinical and environmental subgroups of Legionella pneumophila sequence type 1.PloS one · 2018Article
- Multiplication of Legionella pneumophila Sequence Types 1, 47, and 62 in Buffered Yeast Extract Broth and Biofilms Exposed to Flowing Tap Water at Temperatures of 38°C to 42°C.Applied and environmental microbiology · 2016Article
- Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently.Genome research · 2016Article
- Presence and Persistence of Viable, Clinically Relevant Legionella pneumophila Bacteria in Garden Soil in the Netherlands.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionnaires' disease (LD) is an acute pneumonia caused by the inhalation or aspiration of aerosols contaminated with Legionella bacteria. The watery environment is considered to be the natural habitat for these bacteria. Therefore, drinking water legislation is used in the primary prevention of LD, focussing on the different water sources to which the general public is exposed. For 10 years, secondary prevention of LD in the Netherlands has been organised using an outbreak detection programme that eliminates potential sources of infection that LD patients have been exposed to during their incubation period. To evaluate the two prevention strategies, we compared the distribution of Legionella pneumophila serogroup 1 genotypes isolated from patient material (n = 179) with the distribution resulting from primary (n = 182) and secondary (n = 60) prevention actions, respectively. The sequence type profiles were generated using the HiMLST method that employs next generation sequencing. We found that genotypes collected during primary prevention differ to a large extent from those isolated from patients. Genotypes collected during secondary prevention efforts had a greater similarity to that of patient isolates, but could be further improved. Our results suggest that primary prevention is not aiming at the correct reservoir, whereas secondary prevention is only partially focussed. It seems that there is a still unknown reservoir.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.