ArticleEuropean radiology2013
Diagnostic accuracy of combined coronary angiography and adenosine stress myocardial perfusion imaging using 320-detector computed tomography: pilot study.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Patient satisfaction with coronary CT angiography, myocardial CT perfusion, myocardial perfusion MRI, SPECT myocardial perfusion imaging and conventional coronary angiography.European radiology · 2015Trial
- Dose reduction in dynamic CT stress myocardial perfusion imaging: comparison of 80-kV/370-mAs and 100-kV/300-mAs protocols.European radiology · 2014Trial
- 320-row CT coronary angiography predicts freedom from revascularisation and acts as a gatekeeper to defer invasive angiography in stable coronary artery disease: a fractional flow reserve-correlated study.European radiology · 2014Trial
- Combined coronary angiography and myocardial perfusion by computed tomography in the identification of flow-limiting stenosis - The CORE320 study: An integrated analysis of CT coronary angiography and myocardial perfusion.Journal of cardiovascular computed tomographyTrial
- Area-Detector Computed Tomography for Pulmonary Functional Imaging.Diagnostics (Basel, Switzerland) · 2023Review
- Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT.Arquivos brasileiros de cardiologia · 2019Observational
- Hemodynamic impact of coronary stenosis using computed tomography: comparison between noninvasive fractional flow reserve and 3D fusion of coronary angiography with stress myocardial perfusion.The international journal of cardiovascular imaging · 2019Article
- Fusion of Three-Dimensional Echocardiographic Regional Myocardial Strain with Cardiac Computed Tomography for Noninvasive Evaluation of the Hemodynamic Impact of Coronary Stenosis in Patients with Chest Pain.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2018Article
- CT Myocardial Perfusion Imaging: A New Frontier in Cardiac Imaging.BioMed research international · 2018Review
- Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond.Current cardiovascular imaging reports · 2018Review
- Myocardial ischemia testing with computed tomography: emerging strategies.Cardiovascular diagnosis and therapy · 2017Review
- Non-invasive assessment of the haemodynamic significance of coronary stenosis using fusion of cardiac computed tomography and 3D echocardiography.European heart journal. Cardiovascular Imaging · 2017Article
- Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography.Cardiovascular diagnosis and therapy · 2017Review
- Coronary CT angiography in acute chest pain.F1000Research · 2017Review
- Prognostic value of dipyridamole stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a mid-term follow-up study.European radiology · 2016Article
- Update on Computed Tomography Myocardial Perfusion Imaging.Current cardiovascular imaging reports · 2016Article
- Coronary computed tomography angiography for the assessment of chest pain: current status and future directions.The international journal of cardiovascular imaging · 2015Review
- Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements--initial experience with a novel physician-driven algorithm.European radiology · 2015Article
- Evidence for myocardial CT perfusion imaging in the diagnosis of hemodynamically significant coronary artery disease.Cardiovascular diagnosis and therapy · 2015Article
- Myocardial perfusion imaging with cardiac computed tomography: state of the art.Journal of cardiovascular translational research · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the diagnostic accuracy of combined 320-detector row computed tomography coronary angiography (CTA) and adenosine stress CT myocardial perfusion imaging (CTP) in detecting perfusion abnormalities caused by obstructive coronary artery disease (CAD).
methodsTwenty patients with suspected CAD who underwent initial investigation with single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI) were recruited and underwent prospectively-gated 320-detector CTA/CTP and invasive angiography. Two blinded cardiologists evaluated invasive angiography images quantitatively (QCA). A blinded nuclear physician analysed SPECT-MPI images for fixed and reversible perfusion defects. Two blinded cardiologists assessed CTA/CTP studies qualitatively. Vessels/territories with both >50 % stenosis on QCA and corresponding perfusion defect on SPECT-MPI were defined as ischaemic and formed the reference standard.
resultsAll patients completed the CTA/CTP protocol with diagnostic image quality. Of 60 vessels/territories, 17 (28 %) were ischaemic according to QCA/SPECT-MPI criteria. Sensitivity, specificity, PPV, NPV and area under the ROC curve for CTA/CTP was 94 %, 98 %, 94 %, 98 % and 0.96 (P < 0.001) on a per-vessel/territory basis. Mean CTA/CTP radiation dose was 9.2 ± 7.4 mSv compared with 13.2 ± 2.2 mSv for SPECT-MPI (P < 0.001).
conclusionsCombined 320-detector CTA/CTP is accurate in identifying obstructive CAD causing perfusion abnormalities compared with combined QCA/SPECT-MPI, achieved with lower radiation dose than SPECT-MPI. KEY POINTS: • Advances in CT technology provides comprehensive anatomical and functional cardiac information. • Combined 320-detector CTA/adenosine-stress CTP is feasible with excellent image quality. • Combined CTA/CTP is accurate in identifying myocardial ischaemia compared with QCA/SPECT-MPI. • Combined CTA/CTP results in lower patient radiation exposure than SPECT-MPI. • CTA/CTP may become an established imaging technique for suspected CAD.
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