ArticlePsychopharmacology2013
Excessive aggression as model of violence: a critical evaluation of current preclinical methods.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Aggression is not blind: dominance and social history modulate murine responses to social instigation.Psychopharmacology · 2026Article
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment.International journal of molecular sciences · 2025Article
- Delineating Adaptive and Maladaptive Outcomes of Aggression in Mice.Biological psychiatry global open science · 2025Article
- Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice.Biological psychiatry global open science · 2025Article
- Acute social defeat during adolescence promotes long-lasting aggression through activation of the medial amygdala.Frontiers in neuroscience · 2024Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model.Psychopharmacology · 2022Article
- Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice.Nature communications · 2022Article
- Opposing effects of NMDA receptor antagonists on early life stress-induced aggression in mice.Aggressive behavior · 2022Article
- Aggression, Aggression-Related Psychopathologies and Their Models.Frontiers in behavioral neuroscience · 2022Review
- Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.The international journal of biochemistry & cell biology · 2022Review
- Review
- Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.Nature communications · 2021Article
- Potentiation of Divergent Medial Amygdala Pathways Drives Experience-Dependent Aggression Escalation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Regulation of aggressive behaviors by nicotinic acetylcholine receptors: Animal models, human genetics, and clinical studies.Neuropharmacology · 2020Review
- Translational models of adaptive and excessive fighting: an emerging role for neural circuits in pathological aggression.F1000Research · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rationalePreclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area.
objectivesHow valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior?
methodsThe rationale, key methodological features, supporting data, and arguments as well as their disadvantages and limitations of the most frequently used animal models for excessive aggressive behavior are summarized and their validity and reliability are evaluated.
resultsExcessive aggressive behavior is validly and reliably seen in (1) a proportion of feral-derived rats and selectively bred mice; (2) rats with compromised adrenal function resulting in a hypoglucocorticoid state; (3) a significant minority of mice, rats, and monkeys after consumption of a moderate dose of alcohol; and (4) resident animals of various species after social instigation. Limitations of these procedures include restrictive animal research regulations, the requirement of expertise in surgical, pharmacological, and behavioral techniques, and the behaviorally impoverished mouse strains that are used in molecular genetics research. Promising recent initiatives for novel experimental models include aggressive behaviors that are evoked by optogenetic stimulation and induced by the manipulation of early social experiences such as isolation rearing or social stress.
conclusionsOne of the most significant challenges for animal models of excessive, potentially abnormal aggressive behavior is the characterization of distinctive neurobiological mechanisms that differ from those governing species-typical aggressive behavior. Identifying novel targets for effective intervention requires increased understanding of the distinctive molecular, cellular, and circuit mechanisms for each type of abnormal aggressive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.