ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Risk of fracture in patients with Parkinson's disease.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Executive summary: Italian guidelines for diagnosis, risk stratification, and care continuity of fragility fractures 2021.Frontiers in endocrinology · 2023Pooled it
- Alliance between selective serotonin reuptake inhibitors and fracture risk: an updated systematic review and meta-analysis.European journal of clinical pharmacology · 2020Pooled it
- Parkinson's disease and risk of fracture: a meta-analysis of prospective cohort studies.PloS one · 2014Pooled it
- The taste of Parkinson's: How food choices reflect nutritional health.Journal of Parkinson's disease · 2026Article
- Excess risk of fracture in incident Parkinson's disease Medicare beneficiaries.Injury epidemiology · 2026Article
- Classification of fall risk in Parkinson's disease using empirical mode decomposition and machine learning.Frontiers in bioengineering and biotechnology · 2026Article
- Orthopedic manifestations, complications, and outcomes for arthroplasty in patients with Parkinson disease.Bulletin of the Hospital for Joint Disease (2013) · 2025Review
- Incidence of hip fractures in persons with and without Parkinson's disease in Finland: a 15-year longitudinal study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Fractures in Parkinson's Disease: Pathophysiology, Prevention, and Orthopedic Outcomes.Cureus · 2025Review
- Analysis of Incidence and Risk Factors for Periprosthetic Fracture after Total Knee Arthroplasty in South Korea from 2010 to 2020 Based on National Registry Data.Clinics in orthopedic surgery · 2025Article
- Relationship of foot pain with the increased risk of falls in patients with Parkinson's disease.Journal of foot and ankle research · 2024Article
- Hypnotics and injuries among older adults with Parkinson's disease: a nested case-control design.BMC geriatrics · 2023Article
- Operative Treatment of Distal Radius Fractures in Patients With Parkinson Disease.Hand (New York, N.Y.) · 2022Observational
- Fracture risk and impact of osteoporosis in patients with Parkinson's disease: a nationwide database study.Journal of bone and mineral metabolism · 2022Article
- Current Perspectives on the Assessment and Management of Gait Disorders in Parkinson's Disease.Neuropsychiatric disease and treatment · 2021Review
- Surgical outcome of upper extremity fractures in patients with Parkinson's disease.Scientific reports · 2020Article
- Parkinson's disease and osteoporosis: basic and clinical implications.Expert review of endocrinology & metabolism · 2020Review
- The outcome for surgical fixation of distal radial fractures in patients with idiopathic Parkinson's disease: a cohort study.Journal of orthopaedic surgery and research · 2020Article
- Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK.British journal of clinical pharmacology · 2018Article
- Parkinson's disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe aim of the study was to determine fracture risk in incident Parkinson's disease (PD) patients. This study showed that fracture risk assessment may be indicated among patients with PD, in particular when they have recently used selective serotonin re-uptake inhibitors or high-dose antipsychotics, or have a history of fracture, falling, low body mass index (BMI) or renal disease.
introductionPD is a movement disorder associated with falling and detrimental effects on bone. Both are recognized risk factors for fracture. Therefore, the aim was to determine fracture risk in incident PD patients stratified by treatment, severity, duration of disease and related comorbidities.
methodsWe conducted a retrospective cohort study using the UK General Practice Research Database (1987-2011). Each PD patient was matched by age, sex, calendar time and practice to a control patient without history of PD.
resultsWe identified 4,687 incident PD patients. Compared to controls, a statistically significant increased risk was observed for any fracture (adjusted hazard ratio [AHR], 1.89; 95 % confidence interval [CI], 1.67-2.14), osteoporotic fracture (AHR, 1.99; 95 % CI, 1.72-2.30) and hip fracture (AHR 3.08; 95 % CI, 2.43-3.89). Fracture risk further increased with history of fracture, falling, low BMI, renal disease, antidepressant use and use of high-dose antipsychotics.
conclusionThis study showed that incident PD patients have a statistically significant increased risk of fracture. Therefore, fracture risk assessment may be indicated among PD patients, who, besides the general risk factors for fracture, like increasing age and female gender, have recently used selective serotonin re-uptake inhibitors or high-dose antipsychotics or have a history of fracture, falling, low BMI or renal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.