ArticleBiology open2013
Cell-scale dynamic recycling and cortical flow of the actin-myosin cytoskeleton for rapid cell migration.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Actomyosin dynamics in detached cells: linking clutch model to cell migration and cytokinesis.BMC molecular and cell biology · 2025Article
- GMPS inhibits the proliferation and migration of non-small cell lung cancer via the regulation of the DNMT 1/SERPINB2 axis.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Multiple Mechanisms to Regulate Actin Functions: "Fundamental" Versus Lineage-Specific Mechanisms and Hierarchical Relationships.Biomolecules · 2025Review
- Evolution of the Concepts of Architecture and Supramolecular Dynamics of the Plasma Membrane.Membranes · 2023Review
- Light-sheet microscopy reveals dorsoventral asymmetric membrane dynamics of Amoeba proteus during pressure-driven locomotion.Biology open · 2023Article
- Dynamics of Actin Cytoskeleton and Their Signaling Pathways during Cellular Wound Repair.Cells · 2022Article
- Random encounters and amoeba locomotion drive the predation ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Effects of spatial confinement on migratory properties of Dictyostelium discoideum cells.Communicative & integrative biology · 2021Article
- Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway.Journal of cell science · 2020Article
- CaCells · 2020Review
- Dynamin-Like Protein B ofCells · 2019Article
- Article
- Manipulation of cell migration by laserporation-induced local wounding.Scientific reports · 2019Article
- Article
- Getting in shape and swimming: the role of cortical forces and membrane heterogeneity in eukaryotic cells.Journal of mathematical biology · 2018Article
- A study of wound repair in Dictyostelium cells by using novel laserporation.Scientific reports · 2018Article
- Turnover and flow of the cell membrane for cell migration.Scientific reports · 2017Article
- Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effect of Pseudopod Extensions on Neutrophil Hemodynamic Transport Near a Wall.Cellular and molecular bioengineering · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin and myosin II play major roles in cell migration. Whereas pseudopod extension by actin polymerization has been intensively researched, less attention has been paid to how the rest of the actin cytoskeleton such as the actin cortex contributes to cell migration. In this study, cortical actin and myosin II filaments were simultaneously observed in migrating Dictyostelium cells under total internal reflection fluorescence microscopy. The cortical actin and myosin II filaments remained stationary with respect to the substratum as the cells advanced. However, fluorescence recovery after photobleaching experiments and direct observation of filaments showed that they rapidly turned over. When the cells were detached from the substratum, the actin and myosin filaments displayed a vigorous retrograde flow. Thus, when the cells migrate on the substratum, the cortical cytoskeleton firmly holds the substratum to generate the motive force instead. The present studies also demonstrate how myosin II localizes to the rear region of the migrating cells. The observed dynamic turnover of actin and myosin II filaments contributes to the recycling of their subunits across the whole cell and enables rapid reorganization of the cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.