SynthesisDysphagia2013
Systematic review of dose--volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer.
Synthesis in Dysphagia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04359199 (QUantitative Assessment of Swallowing After Radiation), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
QUantitative Assessment of Swallowing After Radiation (QUASAR): A Longitudinal Comparison of Swallowing Function by Systemic Therapy in Head and Neck Cancer Patients
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Physiological changes to the swallowing mechanism following (chemo)radiotherapy for head and neck cancer: a systematic review.Dysphagia · 2013Pooled it
- The Changes in Pharyngeal Constrictor Muscles Related to Head and Neck Radiotherapy: A Systematic Review.Technology in cancer research & treatmentPooled it
- Trial
- Clinical factors impacting on late dysphagia following radiotherapy in patients with head and neck cancer.The British journal of radiology · 2018Trial
- Quantitative Videofluoroscopic Analysis of Postoperative Swallowing Outcomes in Patients with Oral and Oropharyngeal Cancer.Iranian journal of otorhinolaryngology · 2026Article
- Deep learning NTCP model for late dysphagia after radiotherapy for head and neck cancer patients based on 3D dose, CT and segmentations.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
- Management of HPV+ head and neck squamous cell carcinoma with unknown primary in the era of treatment de-escalation.Oral oncology · 2025Article
- Time to Onset of Dysphagia Following Head and Neck Radiation.Dysphagia · 2025Article
- Post-operative intensity-modulated vs 3D conformal radiotherapy after conservative surgery for laryngeal tumours of the supraglottic region: a dosimetric analysis on 20 patients.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Article
- Article
- Postoperative radiotherapy for supraglottic cancer on real-world data: can we reduce dose to lymph node levels?Radiation oncology (London, England) · 2023Article
- Estimating the optimal linear combination of predictors using spherically constrained optimization.BMC bioinformatics · 2022Article
- The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors.Dysphagia · 2022Article
- Investigating factors associated to dysphagia and need for percutaneous endoscopic gastrostomy in patients with head and neck cancer receiving radiation therapy.Journal of Cancer · 2022Article
- Report on Late Toxicity in Head-and-Neck Tumor Patients with Long Term Survival after Radiochemotherapy.Cancers · 2021Article
- Inter-Observer Variation in Delineating the Pharyngeal Constrictor Muscle as Organ at Risk in Radiotherapy for Head and Neck Cancer.Frontiers in oncology · 2021Article
- Early-Stage Glottic Squamous Cell Carcinoma in the Era of Image-Guided Radiotherapy.Frontiers in oncology · 2021Review
- Phase I dose-escalation trial of S-1 combined with carbon-ion radiotherapy for sinonasal squamous cell carcinoma.Journal of radiation research · 2020Article
- Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours.Dysphagia · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe analyzed published dose-volume data of the structures related to late radiotherapy-induced swallowing disturbances in head-and-neck cancer to estimate their sensitivity, specificity, and predictive value and to propose minimal criteria for future studies.
methodsWe performed a systematic literature search to identify dose-volume correlates with late swallowing disturbances. Study design, dose-volume data, toxicity evaluation, and statistical methods were considered in the analysis.
resultsSeven studies were found, among which one prospective study reported exact dose-volume correlates for individual swallowing structures. Four studies identified dose-volume correlates without reporting exact numbers. One study did not find any correlate of dose-volume data of the swallowing structures with late swallowing disturbances. Variations in patient characteristics, study design, methodology, and statistics made any comparison difficult. However, mean dose to the pharyngeus constrictor muscles appeared to be the most demonstrative predictor of late swallowing disturbances, e.g., reducing the mean dose to the pharyngeal constrictor muscles from 61-64 to 52-55 Gy resulted in fewer swallowing disturbances. There were no available data to estimate sensitivity, specificity, or predictive value of the reported dose-volume correlates.
conclusionMean dose to the pharyngeal constrictor muscles appeared to be the most important dosimetric predictor of late swallowing disturbances. Suggested dose-volume correlates require validation in prospective well-designed clinical trials, applying appropriate statistical methods that would account for possible interfering factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.