ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Mechanical effects of muscle contraction increase intravascular ATP draining quiescent and active skeletal muscle in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.The Journal of physiology · 2022Trial
- Plasma Nucleotide Dynamics during Exercise and Recovery in Highly Trained Athletes and Recreationally Active Individuals.BioMed research international · 2018Trial
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- KThe Journal of physiology · 2020Article
- Vascular reactivity of cutaneous circulation to brief compressive stimuli, in the human forearm.European journal of applied physiology · 2020Article
- Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data.Frontiers in physiology · 2020Article
- Rapid-onset vasodilator responses to exercise in humans: Effect of increased baseline blood flow.Experimental physiology · 2020Article
- Reduced deformability contributes to impaired deoxygenation-induced ATP release from red blood cells of older adult humans.The Journal of physiology · 2019Article
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- Elevated extracellular potassium prior to muscle contraction reduces onset and steady-state exercise hyperemia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Reliability of forearm oxygen uptake during handgrip exercise: assessment by ultrasonography and venous blood gas.Physiological reports · 2018Article
- Hyper-Oxygenation Attenuates the Rapid Vasodilatory Response to Muscle Contraction and Compression.Frontiers in physiology · 2018Article
- Single passive leg movement assessment of vascular function: contribution of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Vasoconstrictor responsiveness in contracting human muscle: influence of contraction frequency, contractile work, and metabolic rate.European journal of applied physiology · 2017Article
- Regulation of skeletal muscle blood flow during exercise in ageing humans.The Journal of physiology · 2016Review
- Effect of ThermaCare HeatWraps and Icy Hot Cream/Patches on Skin and Quadriceps Muscle Temperature and Blood Flow.Journal of chiropractic medicine · 2016Article
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Role of α-adrenergic vasoconstriction in regulating skeletal muscle blood flow and vascular conductance during forearm exercise in ageing humans.The Journal of physiology · 2014Article
- KIR channel activation contributes to onset and steady-state exercise hyperemia in humans.American journal of physiology. Heart and circulatory physiology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Intravascular adenosine triphosphate (ATP) evokes vasodilation and is implicated in the regulation of skeletal muscle blood flow during exercise. Mechanical stresses to erythrocytes and endothelial cells stimulate ATP release in vitro. How mechanical effects of muscle contractions contribute to increased plasma ATP during exercise is largely unexplored. We tested the hypothesis that simulated mechanical effects of muscle contractions increase [ATP](venous) and ATP effluent in vivo, independent of changes in tissue metabolic demand, and further increase plasma ATP when superimposed with mild-intensity exercise. In young healthy adults, we measured forearm blood flow (FBF) (Doppler ultrasound) and plasma [ATP](v) (luciferin-luciferase assay), then calculated forearm ATP effluent (FBF×[ATP](v)) during rhythmic forearm compressions (RFC) via a blood pressure cuff at three graded pressures (50, 100, and 200 mmHg; Protocol 1; n = 10) and during RFC at 100 mmHg, 5% maximal voluntary contraction rhythmic handgrip exercise (RHG), and combined RFC + RHG (Protocol 2; n = 10). [ATP](v) increased from rest with each cuff pressure (range 144-161 vs. 64 ± 13 nmol/l), and ATP effluent was graded with pressure. In Protocol 2, [ATP](v) increased in each condition compared with rest (RFC: 123 ± 33; RHG: 51 ± 9; RFC + RHG: 96 ± 23 vs. Mean Rest: 42 ± 4 nmol/l; P < 0.05), and ATP effluent was greatest with RFC + RHG (RFC: 5.3 ± 1.4; RHG: 5.3 ± 1.1; RFC + RHG: 11.6 ± 2.7 vs. Mean Rest: 1.2 ± 0.1 nmol/min; P < 0.05). We conclude that the mechanical effects of muscle contraction can 1) independently elevate intravascular ATP draining quiescent skeletal muscle without changes in local metabolism and 2) further augment intravascular ATP during mild exercise associated with increases in metabolism and local deoxygenation; therefore, it is likely one stimulus for increasing intravascular ATP during exercise in humans.
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