Evidence map›Paper›PMID 23429765›Full record

ArticleLab on a chip2013

Microfluidic oscillators with widely tunable periods.

Sung-Jin Kim, Ryuji Yokokawa, Shuichi Takayama

Abstract read
In one paragraph

Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Periodic Flows in Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pneumatic oscillator circuits for timing and control of integrated microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sung-Jin KimDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ryuji Yokokawa
Shuichi Takayama

Funding

Microfluidic Tissue Engineering of Small Airway InjuriesR01HL084370 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAKAYAMA, SHUICHI · 2006 to 2010
$2.8M
Microfluidic Analysis of Oscillatory Signaling Pathways Using Phase LockingR01GM096040 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAKAYAMA, SHUICHI · 2011 to 2014
$1.1M
NHLBI NIH HHS HL084370-05NHLBI NIH HHS R01 HL084370NIGMS NIH HHS GM096040-01NIGMS NIH HHS R01 GM096040
6 · The paper itself

Abstract

We present experiments and theory of a constant flow-driven microfluidic oscillator with widely tunable oscillation periods. This oscillator converts two constant input-flows from a syringe pump into an alternating, periodic output-flow with oscillation periods that can be adjusted to between 0.3 s to 4.1 h by tuning an external membrane capacitor. This capacitor allows multiple adjustable periods at a given input flow-rate, thus providing great flexibility in device operation. Also, we show that a sufficiently large external capacitance, relative to the internal capacitance of the microfluidic valve itself, is a critical requirement for oscillation. These widely tunable microfluidic oscillators are envisioned to be broadly useful for the study of biological rhythms, as on-chip timing sources for microfluidic logic circuits, and other applications that require variation in timed flow switching.

Indexed as

Circadian RhythmDimethylpolysiloxanesMicrofluidic Analytical TechniquesModels, TheoreticalbaysilonDimethylpolysiloxanes

Identifiers

PMID23429765
PMCPMC3604044

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.