ArticleBiology open2013
Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Multi-omics and low-input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos.FEBS open bio · 2026Article
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- Significance of the association between early embryonic development and endocytosis.Medical molecular morphology · 2022Review
- Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors.Stem cell research & therapy · 2022Article
- Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei.Scientific reports · 2021Article
- The neglected part of early embryonic development: maternal protein degradation.Cellular and molecular life sciences : CMLS · 2020Review
- Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway.Biology open · 2019Article
- Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes.The Journal of reproduction and development · 2018Article
- Ubiquitin-proteasome system modulates zygotic genome activation in early mouse embryos and influences full-term development.The Journal of reproduction and development · 2018Article
- Activation of β-catenin causes defects in embryonic development during maternal-to-zygotic transition in mice.International journal of clinical and experimental pathology · 2018Article
- Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.Nature communications · 2017Article
- Proteasome Structure and Assembly.Journal of molecular biology · 2017Review
- Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.Journal of developmental biology · 2016Review
- Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of Cancer.Frontiers in oncology · 2015Review
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- Possible role of ZPAC, zygote-specific proteasome assembly chaperone, during spermatogenesis in the mouse.The Journal of reproduction and development · 2014Article
- Functional analysis of nocturnin, a circadian deadenylase, at maternal-to-zygotic transition in mice.The Journal of reproduction and development · 2013Article
- Reorganization, specialization, and degradation of oocyte maternal components for early development.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the maternal-to-zygotic transition (MZT), maternal proteins in oocytes are degraded by the ubiquitin-proteasome system (UPS), and new proteins are synthesized from the zygotic genome. However, the specific mechanisms underlying the UPS at the MZT are not well understood. We identified a molecule named zygote-specific proteasome assembly chaperone (ZPAC) that is specifically expressed in mouse gonads, and expression of ZPAC was transiently increased at the mouse MZT. ZPAC formed a complex with Ump1 and associated with precursor forms of 20S proteasomes. Transcription of ZPAC genes was also under the control of an autoregulatory feedback mechanism for the compensation of reduced proteasome activity similar to Ump1 and 20S proteasome subunit gene expression. Knockdown of ZPAC in early embryos caused a significant reduction of proteasome activity and decrease in Ump1 and mature proteasomes, leading to accumulation of proteins that need to be degraded at the MZT and early developmental arrest. Therefore, a unique proteasome assembly pathway mediated by ZPAC is important for progression of the mouse MZT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.