ArticleJournal of medical microbiology2013
Prevalence of enteroaggregative Escherichia coli and its virulence-related genes in a case-control study among children from north-eastern Brazil.
Article in Journal of medical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 94 citations in OpenAlex.
- Antimicrobial Resistance and Comparative Genome Analysis of High-RiskMicroorganisms · 2026Article
- EnteroaggregativeEcoSal Plus · 2025Review
- Microbiology and epidemiology of enteroaggregativeJournal of medical microbiology · 2025Article
- Enteroaggregative Escherichia coli (EAEC) isolates obtained from non-diarrheic children carry virulence factor-encoding genes from Extraintestinal Pathogenic E. Coli (ExPEC).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Association of Putative Virulence Genes with HEp-2 Cell Adherence and Biofilm Production in EnteroaggregativeIndian journal of microbiology · 2024Article
- Plasmid-encoded toxin ofFrontiers in cellular and infection microbiology · 2024Article
- Transposon mutagenesis of atypical enteroaggregativeFrontiers in cellular and infection microbiology · 2023Article
- Genetic and Antimicrobial Resistance Profiles of Mammary PathogenicPathogens (Basel, Switzerland) · 2022Article
- Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children.Scientific reports · 2021Article
- Diversity of Potentially PathogenicMicroorganisms · 2021Article
- Molecular Epidemiology of EnteroaggregativeInternational journal of molecular sciences · 2020Article
- Comparative analysis of virulence determinants, phylogroups, and antibiotic susceptibility patterns of typical versus atypical Enteroaggregative E. coli in India.PLoS neglected tropical diseases · 2020Article
- Redefining enteroaggregative Escherichia coli (EAEC): Genomic characterization of epidemiological EAEC strains.PLoS neglected tropical diseases · 2020Article
- Characterization of a novel AraC/XylS-regulated family of N-acyltransferases in pathogens of the order Enterobacterales.PLoS pathogens · 2020Article
- Mixed Aetiology of Diarrhoea in Infants Attending Clinics in the North-West Province of South Africa: Potential for Sub-Optimal Treatment.Pathogens (Basel, Switzerland) · 2020Article
- Article
- Genomic Surveillance of Ceftriaxone-ResistantFrontiers in microbiology · 2020Article
- Genetic and Virulence Profiles of EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Analysis of the Virulence Profile and Phenotypic Features of Typical and Atypical EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Prevalence of Virulence Genes in EnteroaggregativeThe American journal of tropical medicine and hygiene · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Enteroaggregative Escherichia coli (EAEC) is an important agent that causes endemic and epidemic diarrhoeal diseases worldwide. Several EAEC virulence-related genes (VRGs) have been described but their role in the clinical outcome of infection is not completely defined. This study investigated the prevalence of EAEC and potential associations of its VRGs with risk of or protection from diarrhoeal diseases in children from urban communities in north-eastern Brazil. The case-control study included 166 children, who had their stools evaluated for the EAEC diagnostic genes (aaiC and aatA) using PCR. Positive samples were further analysed by multiplex PCR and identified 18 VRGs. EAEC was found in the same proportion in both groups (41%). The plasmid-borne gene encoding a hexosyltransferase homologue (capU) was the most frequently detected (89.6%), followed by dispersin protein (aap, 58.2%) and EAEC HilA homologue (eilA, 57.8%). The AAF/III fimbrial subunit (agg3A) gene was observed at lower frequency (1.5%). Plasmid-encoded toxin (pet) or AAF/II fimbrial subunit (aafA) was associated significantly with disease. AAF/IV fimbrial subunit (agg4A) or hypothetical plasmid-encoded haemolysin (orf61) was detected significantly more in controls than in children with diarrhoea. In addition, one set of genes in combination, aaiC and agg3/4C but lacking agg4A and orf61, was associated with diarrhoea cases; and another one, orf61 in the absence of pet and aafA, was correlated with control children. These data confirm a high prevalence, endemicity and heterogeneity of EAEC strains in the developing urban areas of north-eastern Brazil. Statistical correlation between cases and controls was seen with either isolated or combined sets of genes, suggesting that the pathophysiology of EAEC infection involves a complex and dynamic modulation of several VRGs.
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