ArticleInfection and immunity2013
The Cpx stress response system potentiates the fitness and virulence of uropathogenic Escherichia coli.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 77 citations in OpenAlex.
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- RstAB activates type 1 fimbriae to promote uropathogeniciScience · 2026Article
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- The CpxR response regulator mediates the virulence ofMicrobiology spectrum · 2026Article
- Anti-infective compounds forSustainable microbiology · 2026Review
- AreVirulence · 2025Article
- CRISPRi screening revealsmSystems · 2025Article
- The CpxAR signaling system confers a fitness advantage for flea gut colonization by the plague bacillus.Journal of bacteriology · 2024Article
- The CpxRA two-component system of adherent and invasiveInfection and immunity · 2024Article
- The inner membrane protein YhiM links copper and CpxAR envelope stress responses in uropathogenicmBio · 2024Article
- Mapping niche-specific two-component system requirements in uropathogenicMicrobiology spectrum · 2024Article
- Cpx-signalling innpj antimicrobials and resistance · 2024Article
- ArebioRxiv : the preprint server for biology · 2023Article
- Are envelope stress responses essential for persistence to β-lactams inAntimicrobial agents and chemotherapy · 2023Article
- Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps.Antibiotics (Basel, Switzerland) · 2023Review
- Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor lipoprotein NlpE.Molecular microbiology · 2023Article
- Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential.FEMS microbiology reviews · 2023Article
- The Determination, Monitoring, Molecular Mechanisms and Formation of Biofilm in E. coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract Infections.Pathogens (Basel, Switzerland) · 2023Review
- Genomic characteristics and comparative genomics analysis of Salmonella enterica subsp. enterica serovar Thompson isolated from an outbreak in South Korea.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Strains of uropathogenic Escherichia coli (UPEC) are the primary cause of urinary tract infections, representing one of the most widespread and successful groups of pathogens on the planet. To colonize and persist within the urinary tract, UPEC must be able to sense and respond appropriately to environmental stresses, many of which can compromise the bacterial envelope. The Cpx two-component envelope stress response system is comprised of the inner membrane histidine kinase CpxA, the cytosolic response regulator CpxR, and the periplasmic auxiliary factor CpxP. Here, by using deletion mutants along with mouse and zebrafish infection models, we show that the Cpx system is critical to the fitness and virulence of two reference UPEC strains, the cystitis isolate UTI89 and the urosepsis isolate CFT073. Specifically, deletion of the cpxRA operon impaired the ability of UTI89 to colonize the murine bladder and greatly reduced the virulence of CFT073 during both systemic and localized infections within zebrafish embryos. These defects coincided with diminished host cell invasion by UTI89 and increased sensitivity of both strains to complement-mediated killing and the aminoglycoside antibiotic amikacin. Results obtained with the cpxP deletion mutants were more complicated, indicating variable strain-dependent and niche-specific requirements for this well-conserved auxiliary factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.