ArticleCell death & disease2013
CUL1 promotes trophoblast cell invasion at the maternal-fetal interface.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Trophoblast Fusion Deficiency in Placenta-Related Pregnancy Disorders.Advances in experimental medicine and biology · 2026Review
- Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage.Journal of translational medicine · 2024Article
- Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease.Open medicine (Warsaw, Poland) · 2024Article
- Research progress of E3 ubiquitin ligase regulating biological behavior of human placental trophoblast cells.Frontiers in endocrinology · 2023Review
- Inhibitory effect ofAnnals of translational medicine · 2022Article
- Ubiquitin ligases: guardians of mammalian development.Nature reviews. Molecular cell biology · 2022Review
- Characterization of circular RNA profiles of oviduct reveal the potential mechanism in prolificacy trait of goat in the estrus cycle.Frontiers in physiology · 2022Article
- Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.Molecular human reproduction · 2020Article
- CUL1 Knockdown Attenuates the Adhesion, Invasion, and Migration of Triple-Negative Breast Cancer Cells via Inhibition of Epithelial-Mesenchymal Transition.Pathology oncology research : POR · 2020Article
- The role of SCF ubiquitin-ligase complex at the beginning of life.Reproductive biology and endocrinology : RB&E · 2019Review
- SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression.The Malaysian journal of medical sciences : MJMS · 2019Article
- S100P enhances the motility and invasion of human trophoblast cell lines.Scientific reports · 2018Article
- Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer.Cancer biomarkers : section A of Disease markers · 2017Article
- CUL4A enhances human trophoblast migration and is associated with pre-eclampsia.International journal of clinical and experimental pathology · 2017Article
- GABA A receptor π subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia.International journal of molecular medicine · 2016Article
- Article
- Expression of uPAR in human trophoblast and its role in trophoblast invasion.International journal of clinical and experimental pathology · 2015Article
- LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.Cell death & disease · 2014Article
- Role of IGF2BP3 in trophoblast cell invasion and migration.Cell death & disease · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human trophoblast progenitor cells differentiate via two distinct pathways, to become the highly invasive extravillous cytotrophoblast (CTB) cells (EVT) or fuse to form syncytiotrophoblast. Inadequate trophoblast differentiation results in poor placenta perfusion, or even complications such as pre-eclampsia (PE). Cullin1 (CUL1), a scaffold protein in cullin-based ubiquitin ligases, plays an important role in early embryonic development. However, the role of CUL1 in trophoblast differentiation during placenta development has not been examined. Here we show that CUL1 was expressed in CTB cells and EVT in the first trimester human placentas by immunohistochemistry. CUL1 siRNA significantly inhibited outgrowth of extravillous explants in vitro, as well as invasion and migration of HTR8/SVneo cells of EVT origin. This inhibition was accompanied by decreased gelatinolytic activities of matrix metalloproteinase (MMP)-9 and increased expression of tissue inhibitors of MMPs (TIMP-1 and -2). Consistently, exogenous CUL1 promoted invasion and migration of HTR8/SVneo cells. Notably, CUL1 was gradually decreased during trophoblast syncytialization and CUL1 siRNA significantly enhanced forskolin-induced fusion of choriocarcinoma BeWo cells. CUL1 protein levels in human pre-eclamptic placental villi were significantly lower as compared to their matched control placentas. Taken together, our results suggest that CUL1 promotes human trophoblast cell invasion and dysregulation of CUL1 expression may be associated with PE.
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