ArticleFrontiers in oncology2013
Alternative lengthening of telomeres: remodeling the telomere architecture.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed.
- Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins.EMBO reports · 2025Article
- Article
- From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies.International journal of molecular sciences · 2024Review
- Recent Domains in Telomere and Telomerase Targeting for Accomplished Cancer Therapy.Indian journal of clinical biochemistry : IJCB · 2024Article
- Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos.Journal of ovarian research · 2023Review
- Article
- Telomeres in toxicology: Occupational health.Pharmacology & therapeutics · 2021Review
- Polyadenylated Telomeric Noncoding RNA Functions as a Pivotal Therapeutic Target of Anti-Ageing to Stabilize Telomere Length of ChromosomesFrontiers in pharmacology · 2021Article
- Article
- Article
- SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability.Nature communications · 2019Article
- Emerging roles of telomeric chromatin alterations in cancer.Journal of experimental & clinical cancer research : CR · 2019Review
- Article
- A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes.BMC medical genomics · 2018Article
- Break-Induced Replication: The Where, The Why, and The How.Trends in genetics : TIG · 2018Review
- Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism.Oncotarget · 2018Article
- A new role for human dyskerin in vesicular trafficking.FEBS open bio · 2017Article
- Break induced replication in eukaryotes: mechanisms, functions, and consequences.Critical reviews in biochemistry and molecular biology · 2017Review
- Review
- The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children.Journal of neuro-oncology · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies semi-conservative DNA replication. While the majority of human cancers do this by up-regulating telomerase enzyme activity, most of the remainder use a homologous recombination-mediated mechanism of telomere elongation known as alternative lengthening of telomeres (ALT). Many molecular details of the ALT pathway are unknown, and even less is known regarding the mechanisms by which this pathway is activated. Here, we review current findings about telomere structure in ALT cells, including DNA sequence, shelterin content, and heterochromatic state. We speculate that remodeling of the telomere architecture may contribute to the emergence and maintenance of the ALT phenotype.
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