ArticleInternational journal of molecular sciences2013
Preparation of Chitosan and Water-Soluble Chitosan Microspheres via Spray-Drying Method to Lower Blood Lipids in Rats Fed with High-Fat Diets.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Bioactive Chitosan Oligosaccharides Derived from Crab Shell Waste Stimulate Osteogenic Differentiation in Pre-Osteoblast Cells.Marine drugs · 2026Article
- Effects of Antigen Dosage and Chitosan Micro/Nanoparticle Size on Immune Responses in Mice Immunized with H5N1 Influenza Vaccine.Polymers · 2026Article
- Synthesis of Chitosan Oligosaccharide-Loaded Glycyrrhetinic Acid Functionalized Mesoporous Silica Nanoparticles and In Vitro Verification of the Treatment of APAP-Induced Liver Injury.Molecules (Basel, Switzerland) · 2023Article
- A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials.Journal of materials science. Materials in medicine · 2022Article
- Pre-protective effects of dietary chitosan supplementation against oxidative stress induced by diquat in weaned piglets.Cell stress & chaperones · 2018Article
- The effects of COST on the differentiation of 3T3-L1 preadipocytes and the mechanism of action.Saudi journal of biological sciences · 2017Article
- Complex Relationship between Obesity and the Fat Mass and Obesity Locus.International journal of biological sciences · 2017Review
- Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles.Molecules (Basel, Switzerland) · 2016Article
- The effect of chitooligosaccharides on oleic acid-induced lipid accumulation in HepG2 cells.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Article
- Hypolipidemic effects of chitosan and its derivatives in hyperlipidemic rats induced by a high-fat diet.Food & nutrition research · 2016Article
- Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL.International journal of molecular sciences · 2015Review
- Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats.Marine drugs · 2015Article
- Development of microspheres for biomedical applications: a review.Progress in biomaterials · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This experiment aimed to investigate the effects of the chitosan (CTS) and water-soluble chitosan (WSC) microspheres on plasma lipids in male Sprague-Dawley rats fed with high-fat diets. CTS microspheres and WSC microspheres were prepared by the spray-drying technique. Scanning electron microscopy (SEM) micrographs showed that the microspheres were nearly spherical in shape. The mean size of CTS microspheres was 4.07 μm (varying from 1.50 to 7.21 μm) and of WSC microspheres was 2.00 μm (varying from 0.85 to 3.58 μm). The rats were classified into eight groups (n = 8) and were fed with high-fat diets for two weeks to establish the hyperlipidemic condition and were then treated with CTS microspheres and WSC microspheres, CTS and WSC for four weeks. The results showed that CTS and WSC microspheres reduced blood lipids and plasma viscosity and increased the serum superoxide dismutase (SOD) levels significantly. This study is the first report of the lipid-lowering effects of CTS and WSC microspheres. CTS and WSC microspheres were found to be more effective in improving hyperlipidemia in rats than common CTS and WSC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.