ArticleInternational journal of molecular sciences2013
Brain metastasis in pancreatic cancer.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Risk prediction model for brain metastasis risk among patients diagnosed with primary gastrointestinal cancers.British journal of cancer · 2026Article
- Multifocal hemorrhagic metastases with cerebellar predominance following prolonged remission of pancreatic adenocarcinoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A Rare Case of Simultaneous Brain and Leptomeningeal Metastases in a Patient With Pancreatic Cancer.Cureus · 2025Article
- Cerebellopontine angle metastasis from pancreatic cancer: a case report.Annals of medicine and surgery (2012) · 2025Article
- Clinical and molecular characteristics of patients with brain metastasis secondary to pancreatic ductal adenocarcinoma.The oncologist · 2025Article
- Biological Barriers for Drug Delivery and Development of Innovative Therapeutic Approaches in HIV, Pancreatic Cancer, and Hemophilia A/B.Pharmaceutics · 2024Review
- Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers.Cancers · 2024Article
- Late metachronous cerebral metastasis of pancreatic adenocarcinoma of the tail of the pancreas: a case report.Journal of medical case reports · 2022Article
- Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis.Frontiers in cell and developmental biology · 2022Review
- Towards updated understanding of brain metastasis.American journal of cancer research · 2022Review
- Combined modality therapy including cytoreductive surgery and heated intraperitoneal chemotherapy for synchronous low volume peritoneal carcinomatosis from adenocarcinoma of the tail of pancreas in a BRCA-2 carrier resulting in long-term disease-free survival: A case report.International journal of surgery case reports · 2021Article
- Incidence and survival outcomes of secondary liver cancer: a Surveillance Epidemiology and End Results database analysis.Translational cancer research · 2021Article
- Prognostic Factors of Survival in Pancreatic Cancer Metastasis to Liver at Different Ages of Diagnosis: A SEER Population-Based Cohort Study.Frontiers in big data · 2021Article
- MicroRNA-1469-5p promotes the invasion and proliferation of pancreatic cancer cells via direct regulating the NDRG1/NF-κB/E-cadherin axis.Human cell · 2020Article
- LINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2.Cell death & disease · 2019Article
- Development and validation of a nomogram to predict liver metastasis in patients with pancreatic ductal adenocarcinoma: a large cohort study.Cancer management and research · 2019Article
- Occipital Headache as Initial Manifestation of a Pancreatic Neuroendocrine Tumor.Journal of gastrointestinal cancer · 2018Article
- CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells.Scientific reports · 2018Article
- Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis.World journal of gastroenterology · 2017Observational
- Oligometastatic Disease in Pancreatic Cancer - How to Proceed?Visceral medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer is a fatal disease with a 5-year survival rate below 5%. Most patients are diagnosed at an advanced tumor stage and existence of distant metastases. However, involvement of the central nervous system is rare in pancreatic cancer. We retrospectively analyzed all cases of brain metastases in pancreatic cancer reported to date focusing on patient characteristics, clinical appearance, therapy and survival. Including our own, 12 cases of brain metastases originating from pancreatic cancer were identified. In three patients brain metastases were the first manifestation of pancreatic cancer. All other patients developed brain metastases during their clinical course. In most cases, the disease progressed rapidly and the patients died within weeks or months. However, two patients showed long-term survival. Of note, both patients received resection of the pancreatic cancer as well as curative resection of the metachronous brain metastases. Brain metastases in pancreatic cancer are a rare condition and usually predict a very poor prognosis. However, there is evidence that resection of brain metastases of pancreatic cancer can be immensely beneficial to patient's survival, even with the chance for cure. Therefore, a surgical approach in metastatic pancreatic cancer should be considered in selective cases.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.