ArticleCell cycle (Georgetown, Tex.)2013
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21.Communications biology · 2023Article
- CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.Molecular biology of the cell · 2021Article
- USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.International journal of molecular sciences · 2021Article
- Squamous differentiation requires G2/mitosis slippage to avoid apoptosis.Cell death and differentiation · 2020Article
- Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit.Cells · 2020Article
- Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish.Cellular and molecular life sciences : CMLS · 2018Article
- VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.Cellular and molecular life sciences : CMLS · 2018Article
- Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells.Molecular and cellular biochemistry · 2016Article
- Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response.Scientific reports · 2016Article
- An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.Cell death and differentiation · 2016Article
- Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.Molecular and cellular biology · 2015Article
- Review
- Article
- Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species.The Journal of biological chemistry · 2014Article
- DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.Cell death & disease · 2014Article
- A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition.Cell cycle (Georgetown, Tex.) · 2013Article
- Aurora B: hooking up with cyclin-dependent kinases.Cell cycle (Georgetown, Tex.) · 2013Article
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5 authors.
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Abstract
Aurora kinase B is a critical component of the chromosomal passenger complex, which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. By using conditional knockout cells and chemical inhibition, we show here that inactivation of Aurora B results in delayed G(1)/S transition and premature mitotic exit. Aurora B deficiency results in delayed DNA replication in cultured fibroblasts as well as liver cells after hepatectomy. This is accompanied by increased transcription of the cell cycle inhibitor p21 (Cip1). Lack of Aurora B does not prevent mitotic entry but results in a premature exit from prometaphase in the presence of increased p21(Cip1)-Cdk1 inactive complexes. Aurora B-null cells display reduced degradation of cyclin B1, suggesting the presence of phenomenon known as adaptation to the mitotic checkpoint, previously described in yeast. Elimination of p21(Cip1) rescues Cdk1 activity and prevents premature mitotic exit in Aurora B-deficient cells. These results suggest that Aurora B represses p21(Cip1), preventing delayed DNA replication, Cdk inhibition and premature mitotic exit. The upregulation of p21(Cip1) observed after inhibition of Aurora B may have important implications in cell cycle progression, tetraploidy, senescence or cancer therapy.
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