ReviewArthritis research & therapy2013
The role of the circadian clock in rheumatoid arthritis.
Review in Arthritis research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Effect of timed exercise interventions on patient-reported outcome measures: A systematic review.PloS one · 2025Pooled it
- Chronotype in Patients With Immune-Mediated Inflammatory Disease: A Systematic Review.Journal of biological rhythms · 2023Pooled it
- Psychometric properties of morning joint stiffness duration and severity measures in patients with moderately to severely active rheumatoid arthritis.Health and quality of life outcomes · 2017Trial
- Body mass index links night work intensity with higher low-grade systemic inflammation: results from a field study in humans.International archives of occupational and environmental health · 2026Article
- Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Diurnal Variation, Topographical Distribution and Day-to-Day Repeatability of Ocular Surface Epithelial Immune Cells in Individuals with Dry Eye Disease.Journal of clinical medicine · 2026Article
- Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews.Rheumatology (Oxford, England) · 2025Article
- Sleep and circadian parameters in Behçet's syndrome: a comparative analysis using actigraphy and questionnaires.Rheumatology (Oxford, England) · 2025Article
- Circadian Clock: A Regulator of Immunity in Autoimmune Diseases.Immunity, inflammation and disease · 2025Review
- Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways.Journal of biological engineering · 2025Review
- Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy.Scientific reports · 2025Article
- Time-restricted feeding alleviates arthritis symptoms augmented by high-fat diet.Frontiers in immunology · 2025Article
- Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024Review
- Juvenile Idiopathic Arthritis.Indian journal of pediatrics · 2024Review
- Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.Open biology · 2024Article
- Is it possible to objectively determine morning stiffness in rheumatoid arthritis?Turkish journal of physical medicine and rehabilitation · 2024Article
- Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice.Cells · 2024Article
- Clinically relevant differences in spinal mobility related to daytime performance in patients with axial spondyloarthritis.RMD open · 2024Observational
- Circadian clock disruption in autoimmune thyroiditis.European thyroid journal · 2023Article
- The Associations of Chronotype and Shift Work With Rheumatoid Arthritis.Journal of biological rhythms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis exhibits diurnal variation in symptoms, with patients suffering with increased painful joint stiffness in the early morning. This correlates with an early morning rise in circulating levels of pro-inflammatory cytokines, such as interleukin-6. This temporal variation in disease pathology is directed by the circadian clock, both at a systemic level, through signalling pathways derived in the central clock, and at a local level by autonomous clocks found within inflammatory organs and cells. Indeed, many cellular components of the immune system, which are involved in the pathogenesis of rheumatoid arthritis, possess independent clocks that facilitate temporal gating of their functions. Furthermore, the circadian clock regulates the expression and activity of several genes and proteins that have demonstrated roles in progression of this autoimmune disease. These include a number of nuclear receptors and also fat-derived adipokines. Employing the knowledge we have about how the inflammatory response is regulated by the clock will facilitate the development of chronotherapy regimens to improve the efficacy of current treatment strategies. Furthermore, a full understanding of the mechanisms by which the clock couples to the immune system may provide novel therapeutic targets for the treatment of this debilitating disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.