Evidence map›Paper›PMID 23427306›Full record

ArticleJournal of neurophysiology2013

Comprehensive phenotyping of group III and IV muscle afferents in mouse.

Michael P Jankowski, Kristofer K Rau, Katrina M Ekmann, Collene E Anderson, H Richard Koerber

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 138 citations in OpenAlex.

  1. Trial
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  5. A who's who of cell types in skeletal muscle.Communications biology · 2026
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  9. The sarcopenia-pain connection: why mechanisms matter for patient care?Frontiers in pain research (Lausanne, Switzerland) · 2026
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael P JankowskiDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Kristofer K Rau
Katrina M Ekmann
Collene E Anderson
H Richard Koerber
University of Pittsburgh · US

Funding

Peripheral Nerve Regeneration and Sensory Neuron PlasticityR01NS023725 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD · 1986 to 2017
$5.9M
Primary and Secondary Nociceptors in Persistent PainR01NS052848 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD · 2006 to 2010
$1.6M
Peripheral Nerve Regeneration and Sensory Neuron PlasticityR56NS023725 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD · 2008 to 2008
$331k
Neurotrophic factor regulation of regenerated sensory neuron response propertiesF32NS061487 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JANKOWSKI, MICHAEL P · 2008 to 2009
$101k
NINDS NIH HHS F32 NS-061487NINDS NIH HHS NS-023725NINDS NIH HHS NS-052848NINDS NIH HHS R01 NS023725
6 · The paper itself

Abstract

While much is known about the functional properties of cutaneous nociceptors, relatively little is known about the comprehensive functional properties of group III and IV muscle afferents. We have developed a mouse ex vivo forepaw muscle, median and ulnar nerve, dorsal root ganglion (DRG), spinal cord recording preparation to examine the functional response properties, neurochemical phenotypes, and spinal projections of individual muscle afferents. We found that the majority of group III and IV muscle afferents were chemosensitive (52%) while only 34% responded to mechanical stimulation and fewer (32%) responded to thermal stimuli. The chemosensitive afferents could be grouped into those that responded to a "low"-metabolite mixture containing amounts of lactate and ATP at pH 7.0 simulating levels observed in muscle during exercise (metaboreceptors) and a "high"-metabolite mixture containing lactic acid concentrations and ATP at pH 6.6 mimicking levels observed during ischemic contractions (metabo-nociceptors). While the majority of the metabo-nociceptive fibers responding to the higher concentration levels were found to contain acid-sensing ion channel 3 (ASIC3) and/or transient receptor potential vanilloid type 1 (TRPV1), metaboreceptors responding to the lower concentration levels lacked these receptors. Anatomically, group III muscle afferents were found to have projections into laminae I and IIo, and deeper laminae in the spinal cord, while all functional types of group IV muscle afferents projected primarily into both laminae I and II. These results provide novel information about the variety of sensory afferents innervating the muscle and provide insight into the types of fibers that may exhibit plasticity after injuries.

Indexed as

PhenotypeAcid Sensing Ion ChannelsAction PotentialsAdenosine TriphosphateAfferent PathwaysAnimalsForelimbGanglia, SpinalLactic AcidMaleMiceMice, Inbred StrainsMuscle, SkeletalNociceptorsSpinal CordTRPV Cation ChannelsAcid Sensing Ion ChannelsAdenosine TriphosphateASIC3 protein, mouseLactic AcidTRPV1 protein, mouseTRPV Cation Channelsdorsal root ganglionmetaboreceptorsnociceptorsspinal cord

Identifiers

PMID23427306
PMCPMC3652219
OpenAlexW2049790162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.