ArticleJournal of immunology (Baltimore, Md. : 1950)2013
The inflammatory twitch as a general strategy for controlling the host response.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Multi-scale models of lung fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Agent-based models of inflammation in translational systems biology: A decade later.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Pathophysiology to Phenotype in the Asthma of Obesity.Annals of the American Thoracic Society · 2017Review
- Systems physiology of the airways in health and obstructive pulmonary disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Mouse Modeling of Obese Lung Disease. Insights and Caveats.American journal of respiratory cell and molecular biology · 2016Review
- Dissecting the inflammatory twitch in allergically inflamed mice.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- A Computational Model of Cellular Engraftment on Lung Scaffolds.BioResearch open access · 2016Article
- A computational model of unresolved allergic inflammation in chronic asthma.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Systems approaches for synthetic biology: a pathway toward mammalian design.Frontiers in physiology · 2013Article
- The immune profile associated with acute allergic asthma accelerates clearance of influenza virus.Immunology and cell biologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Allergic inflammation is a general host-defense mechanism for dealing with perceived foreign invaders. Although most effort has been directed toward understanding how this response gets turned on, how it gets turned off again when no longer needed is just as important to an organism's survival. We postulate that the control of the allergic inflammatory response is achieved via frequency modulation whereby a sequence of self-resolving events is repetitively invoked only so long as Ag is present. This leads to the notion of a unitary inflammatory event that we argue has formal similarity to the skeletal muscle twitch, albeit manifest over a much longer time scale. To test the plausibility of this hypothesis, we created an agent-based computational model of the allergic inflammatory response in the lungs. Continual stimulation of the model results in cycles of tissue damage and repair interspersed with periods of nonresponsiveness indicative of a refractory period. These findings are consistent with the inflammatory twitch hypothesis and the notion that the allergic inflammatory response is controlled via frequency modulation. We speculate that chronic inflammatory diseases may represent a failure of the inflammatory twitch to resolve toward baseline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.