ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 89 citations in OpenAlex.
- Varying the hydrophobic core composition of polymeric nanoparticles affects NLRP3 inflammasome activation.Biomaterials science · 2024Article
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- Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems.Macromolecules · 2022Review
- Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective.Advanced nanobiomed research · 2022Article
- Activation of NLRP3 Inflammasome by Virus-Like Particles of Human Polyomaviruses in Macrophages.Frontiers in immunology · 2022Article
- Core Hydrophobicity of Supramolecular Nanoparticles Induces NLRP3 Inflammasome Activation.ACS applied materials & interfaces · 2021Article
- MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Resilin-mimetics as a smart biomaterial platform for biomedical applications.Nature communications · 2021Review
- Protein and Peptide Nanocluster Vaccines.Current topics in microbiology and immunology · 2021Article
- Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes.PLoS pathogens · 2021Article
- Polymeric nanoparticle vaccines to combat emerging and pandemic threats.Biomaterials · 2021Review
- Modulation of Immune Responses by Particle Size and Shape.Frontiers in immunology · 2020Review
- Domesticating the foreign body response: Recent advances and applications.Advanced drug delivery reviews · 2019Review
- Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019Review
- Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses.Nature communications · 2018Article
- Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1.Scientific reports · 2017Article
- The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.Scientific reports · 2017Article
- Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine.Bioengineering & translational medicine · 2017Review
- T cell immunoengineering with advanced biomaterials.Integrative biology : quantitative biosciences from nano to macro · 2017Review
- Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing.Biomaterials science · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Polymeric microparticles have been widely investigated as platforms for delivery of drugs, vaccines, and imaging contrast agents and are increasingly used in a variety of clinical applications. Microparticles activate the inflammasome complex and induce the processing and secretion of IL-1β, a key innate immune cytokine. Recent work suggests that although receptors are clearly important for particle phagocytosis, other physical characteristics, especially shape, play an important role in the way microparticles activate cells. We examined the role of particle surface texturing not only on uptake efficiency but also on the subsequent immune cell activation of the inflammasome. Using a method based on emulsion processing of amphiphilic block copolymers, we prepared microparticles with similar overall sizes and surface chemistries but having either smooth or highly microtextured surfaces. In vivo, textured (budding) particles induced more rapid neutrophil recruitment to the injection site. In vitro, budding particles were more readily phagocytosed than smooth particles and induced more lipid raft recruitment to the phagosome. Remarkably, budding particles also induced stronger IL-1β secretion than smooth particles through activation of the NLRP3 inflammasome. These findings demonstrate a pronounced role of particle surface topography in immune cell activation, suggesting that shape is a major determinant of inflammasome activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.