ArticleJournal of the Royal Society, Interface2013
Quantifying the roles of cell motility and cell proliferation in a circular barrier assay.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Inference and prediction for stochastic models of biological populations undergoing migration and proliferation.Journal of the Royal Society, Interface · 2025Review
- Survivin modulates stiffness-induced vascular smooth muscle cell motility.APL bioengineering · 2025Article
- Modelling collective invasion with reaction-diffusion equations: When does domain curvature matter?Applied mathematics letters · 2025Article
- Discrete and continuous mathematical models of sharp-fronted collective cell migration and invasion.Royal Society open science · 2024Article
- Parameter identifiability and model selection for partial differential equation models of cell invasion.Journal of the Royal Society, Interface · 2024Article
- mAmerican journal of cancer research · 2024Article
- Microfluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration.Scientific reports · 2023Article
- From simplicity to complexity in current melanoma models.Experimental dermatology · 2022Review
- Revisiting Fisher-KPP model to interpret the spatial spreading of invasive cell population in biology.Heliyon · 2022Article
- Nogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling.Cell death & disease · 2022Article
- Investigations on the Wound Healing Potential of Tilapia Piscidin (TP)2-5 and TP2-6.Marine drugs · 2022Article
- Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia.eLife · 2020Article
- Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis.Cell death & disease · 2020Article
- Practical parameter identifiability for spatio-temporal models of cell invasion.Journal of the Royal Society, Interface · 2020Article
- Modelling collective cell migration: neural crest as a model paradigm.Journal of mathematical biology · 2020Article
- A free boundary model of epithelial dynamics.Journal of theoretical biology · 2019Article
- Accurate and efficient discretizations for stochastic models providing near agent-based spatial resolution at low computational cost.Journal of the Royal Society, Interface · 2019Article
- Prion-like spreading of Alzheimer's disease within the brain's connectome.Journal of the Royal Society, Interface · 2019Article
- Revisiting the Fisher-Kolmogorov-Petrovsky-Piskunov equation to interpret the spreading-extinction dichotomy.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Polarization wave at the onset of collective cell migration.Physical review. E · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moving fronts of cells are essential features of embryonic development, wound repair and cancer metastasis. This paper describes a set of experiments to investigate the roles of random motility and proliferation in driving the spread of an initially confined cell population. The experiments include an analysis of cell spreading when proliferation was inhibited. Our data have been analysed using two mathematical models: a lattice-based discrete model and a related continuum partial differential equation model. We obtain independent estimates of the random motility parameter, D, and the intrinsic proliferation rate, λ, and we confirm that these estimates lead to accurate modelling predictions of the position of the leading edge of the moving front as well as the evolution of the cell density profiles. Previous work suggests that systems with a high λ/D ratio will be characterized by steep fronts, whereas systems with a low λ/D ratio will lead to shallow diffuse fronts and this is confirmed in the present study. Our results provide evidence that continuum models, based on the Fisher-Kolmogorov equation, are a reliable platform upon which we can interpret and predict such experimental observations.
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