ArticleThe British journal of radiology2013
Relationship between T2 relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume.
Article in The British journal of radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Applications of TFrontiers in oncology · 2022Pooled it
- Preoperative prediction of meningioma grade based on synthetic MRI quantitative T1 and T2 mapping.Japanese journal of radiology · 2026Article
- Quantitative Diffusion and T2 Mapping Using RF-Modulated Phase-Based Gradient Echo Imaging.Magnetic resonance in medicine · 2026Article
- Temporal changes in sucrose phantoms for magnetic resonance imaging: effects of preparation temperatures.Radiological physics and technology · 2025Article
- Cross-Scanner Harmonization of AI/DL Accelerated Quantitative Bi-Parametric Prostate MRI.Sensors (Basel, Switzerland) · 2025Article
- Quantitative Prostate MRI, From theAJR. American journal of roentgenology · 2025Review
- Quantitative magnetic resonance imaging in prostate cancer: A review of current technology.World journal of radiology · 2024Review
- Technical note: hydrogel-based mimics of prostate cancer with matched relaxation, diffusion and kurtosis for validating multi-parametric MRI.Medical physics · 2024Article
- Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue.Magnetic resonance in medicine · 2022Article
- MR fingerprinting of the prostate.Magma (New York, N.Y.) · 2022Review
- Magnetic resonance fingerprinting in prostate cancer before and after contrast enhancement.The British journal of radiology · 2022Article
- Feasibility of Novel Three-Dimensional Magnetic Resonance Fingerprinting of the Prostate Gland: Phantom and Clinical Studies.Korean journal of radiology · 2021Article
- Two-centre comparative experimental study of biparametric MRI at 3.0 T with and without endorectal coil using kiwifruit (Actinidia deliciosa) as a phantom for human prostate.European radiology experimental · 2019Article
- Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping.Investigative radiology · 2019Article
- Incorporating Oxygen-Enhanced MRI into Multi-Parametric Assessment of Human Prostate Cancer.Diagnostics (Basel, Switzerland) · 2017Article
- Development of a Combined MR Fingerprinting and Diffusion Examination for Prostate Cancer.Radiology · 2017Article
- Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness.Molecular imaging and biology · 2017Article
- A novel alternative to classify tissues from T 1 and T 2 relaxation times for prostate MRI.Magma (New York, N.Y.) · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo establish whether T2 relaxation and apparent diffusion coefficient (ADC) in normal prostate and tumour are related and to investigate the effects of glandular compression from an enlarged transition zone (TZ) on peripheral zone (PZ) T2 and ADC by correlating them with the peripheral zone fractional volume (PZFV).
methods48 consecutive patients prospectively underwent multiecho T2 weighted (T2W) (echo times 20, 40, 60, 80, 100 ms) and diffusion-weighted (b=0, 100, 300, 500, 800 s mm(-2)) endorectal MRI. In 43 evaluable patients, single slice whole PZ, TZ and tumour (focal hypointense signal on T2W images in a biopsy-positive octant) regions of interest were transferred to T2 and ADC maps by slice matching. T2 and ADC values were correlated, and PZ values were correlated with PZFV.
resultsT2 and ADC values were significantly different among groups [T2 mean±standard deviation (SD) PZ, 149±49 ms; TZ, 125±26 ms; tumour, 97±23 ms; PZ vs TZ, p=0.002; PZ vs tumour, p<0.0001; TZ vs tumour, p<0.0001; ADC×10(-6) mm(2) s(-1) mean±SD PZ, 1680±215; TZ, 1478±139; tumour, 1030±205; p<0.0001]. Significant positive correlations existed between T2 and ADC for PZ, TZ, PZ and TZ together, but not for tumour (r=0.515, p<0.0001; r=0.300, p=0.03; r=0.526, p<0.0001; and r=0.239, p=0.32, respectively). No significant correlation existed between PZFV and PZ T2 (r=0.10, p=0.5) or ADC (r=0.03, p=0.8).
conclusionThe correlation between T2 and ADC that exists in normal prostate is absent in tumour. PZ compression by an enlarged TZ does not alter PZ T2 or ADC to affect tumour-PZ contrast. ADVANCES IN KNOWLEDGE: Microstructural features of tumours alter diffusivity independently of their effects on T2 relaxation.
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