ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 113 citations in OpenAlex.
- Network analysis identifies consensus physiological measures of neurovascular coupling in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.Neurobiology of aging · 2025Article
- Fading Blue: Exploring the Causes of Locus Coeruleus Damage Across the Lifespan.Antioxidants (Basel, Switzerland) · 2025Review
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry.Advances in neurobiology · 2025Review
- Stimulation of Locus Ceruleus Inputs to the Prelimbic Cortex in Mice Induces Cell Type-Specific Expression of theeNeuro · 2024Article
- Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling.Communications biology · 2024Article
- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease.Handbook of experimental pharmacology · 2024Review
- A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.Neuroscience and biobehavioral reviews · 2023Review
- Pupil dynamics during very light exercise predict benefits to prefrontal cognition.NeuroImage · 2023Article
- Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes viaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.iScience · 2023Article
- Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles.Frontiers in molecular biosciences · 2023Article
- Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI.Frontiers in human neuroscience · 2023Article
- Locus coeruleus ablation in mice: protocol optimization, stereology and behavioral impact.Frontiers in cellular neuroscience · 2023Article
- When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives.International journal of molecular sciences · 2022Review
- Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network.Science advances · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The locus coeruleus (LC), the main source of brain noradrenalin (NA), modulates cortical activity, cerebral blood flow (CBF), glucose metabolism, and blood-brain barrier permeability. However, the role of the LC-NA system in the regulation of cortical CBF has remained elusive. This rat study shows that similar proportions (∼20%) of cortical pyramidal cells and GABA interneurons are contacted by LC-NA afferents on their cell soma or proximal dendrites. LC stimulation induced ipsilateral activation (c-Fos upregulation) of pyramidal cells and of a larger proportion (>36%) of interneurons that colocalize parvalbumin, somatostatin, or nitric oxide synthase compared with pyramidal cells expressing cyclooxygenase-2 (22%, p < 0.05) or vasoactive intestinal polypeptide-containing interneurons (16%, p < 0.01). Concurrently, LC stimulation elicited larger ipsilateral compared with contralateral increases in cortical CBF (52 vs 31%, p < 0.01). These CBF responses were almost abolished (-70%, p < 0.001) by cortical NA denervation with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] and were significantly reduced by α- and β-adrenoceptor antagonists (-40%, p < 0.001 and -30%, p < 0.05, respectively). Blockade of glutamatergic or GABAergic neurotransmission with NMDA or GABA(A) receptor antagonists potently reduced the LC-induced hyperemic response (-56%, p < 0.001 or -47%, p < 0.05). Moreover, inhibition of astroglial metabolism (-35%, p < 0.01), vasoactive epoxyeicosatrienoic acids (EETs; -60%, p < 0.001) synthesis, large-conductance, calcium-operated (BK, -52%, p < 0.05), and inward-rectifier (Kir, -40%, p < 0.05) K+ channels primarily impaired the hyperemic response. The data demonstrate that LC stimulation recruits a broad network of cortical excitatory and inhibitory neurons resulting in increased cortical activity and that K+ fluxes and EET signaling mediate a large part of the hemodynamic response.
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