ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Foxp2 mediates sex differences in ultrasonic vocalization by rat pups and directs order of maternal retrieval.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model.Biology of sex differences · 2025Pooled it
- Characterization of the chromosome 7 locus associated with suicidal behavior.Molecular psychiatry · 2026Article
- Dynamic brain lateralization patterns in Chinese naturalistic language comprehension and association with sex differences: a 7T functional magnetic resonance imaging study.Psychoradiology · 2026Article
- Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia.Scientific reports · 2025Article
- Mountable miniature microphones to identify and assign mouse ultrasonic vocalizations.Cell reports methods · 2025Article
- Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stress.bioRxiv : the preprint server for biology · 2025Article
- Vocal recognition of partners by female prairie voles.iScience · 2025Article
- Article
- Peripartum buprenorphine and oxycodone exposure impair maternal behavior and increase neuroinflammation in new mother rats.Brain, behavior, and immunity · 2025Article
- Genetically diverse mice exhibit divergent domain-specific, sex-dependent behavioral outcomes following exposure to early life stress.PloS one · 2025Article
- The role of cerebellar FOXP1 in the development of motor and communicative behaviors in mice.Genes, brain, and behavior · 2024Article
- Activity of forkhead box P2-positive neurons is associated with tadpole begging behaviour.Biology letters · 2024Article
- Activity of FoxP2-positive neurons is associated with tadpole begging behavior.bioRxiv : the preprint server for biology · 2024Article
- Vocal recognition of partners by female prairie voles.bioRxiv : the preprint server for biology · 2024Article
- Deficiency of the paternally-expressed imprintedFrontiers in neuroscience · 2024Article
- Microglia depletion facilitates the display of maternal behavior and alters activation of the maternal brain network in nulliparous female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Article
- Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model.Translational psychiatry · 2023Article
- Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions.Journal of molecular medicine (Berlin, Germany) · 2023Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
Abstract
The FOXP2 gene is central to acquisition of speech and language in humans and vocal production in birds and mammals. Rodents communicate via ultrasonic vocalizations (USVs) and newborn pups emit distress USVs when separated from their dam, thereby facilitating their retrieval. We observed that isolated male rat pups emitted substantially more USV calls and these were characterized by a significantly lower frequency and amplitude compared with female rat pups. Moreover, the dam was more likely to first retrieve male pups back to the nest, then females. The amount of Foxp2 protein was significantly higher in multiple regions of the developing male brain compared with females and a reduction of brain Foxp2 by siRNA eliminated the sex differences in USVs and altered the order of pup retrieval. Our results implicate Foxp2 as a component of the neurobiological basis of sex differences in vocal communication in mammals. We extended these observations to humans, a species reported to have gender differences in language acquisition, and found the amount of FOXP2 protein in the left hemisphere cortex of 4-year-old boys was significantly lower than in age-matched girls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.