ArticleInternational journal of nanomedicine2013
Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.Journal of animal science and technology · 2023Article
- In Vivo Distribution of Poly(ethylene glycol) Functionalized Iron Oxide Nanoclusters: An Ultrastructural Study.Nanomaterials (Basel, Switzerland) · 2021Article
- Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications.Materials (Basel, Switzerland) · 2019Review
- Synthesis and investigations on tellurium myconanoparticles.Biotechnology reports (Amsterdam, Netherlands) · 2018Article
- Biocompatibility of very small superparamagnetic iron oxide nanoparticles in murine organotypic hippocampal slice cultures and the role of microglia.International journal of nanomedicine · 2017Article
- Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific.Nanomedicine : nanotechnology, biology, and medicine · 2016Article
- Alternating magnetic field-induced hyperthermia increases iron oxide nanoparticle cell association/uptake and flux in blood-brain barrier models.Pharmaceutical research · 2015Article
- Comparison of doxorubicin anticancer drug loading on different metal oxide nanoparticles.Medicine · 2015Article
- Uptake and metabolism of iron oxide nanoparticles in brain cells.Neurochemical research · 2014Review
- A comparison of conventional methods for the quantification of bacterial cells after exposure to metal oxide nanoparticles.BMC microbiology · 2014Article
- Interactions between nanosized materials and the brain.Current medicinal chemistry · 2014Review
- Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood-brain barrier.International journal of nanomedicine · 2014Article
- Optimizing superparamagnetic iron oxide nanoparticles as drug carriers using an in vitro blood-brain barrier model.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the permeability of 11 different iron oxide nanoparticle (IONP) samples (eight fluids and three powders) was determined using an in vitro blood-brain barrier model. Importantly, the results showed that the ferrofluid formulations were statistically more permeable than the IONP powder formulations at the blood-brain barrier, suggesting a role for the presently studied in situ synthesized ferrofluid formulations using poly(vinyl) alcohol, bovine serum albumin, collagen, glutamic acid, graphene, and their combinations as materials which can cross the blood-brain barrier to deliver drugs or have other neurological therapeutic efficacy. Conversely, the results showed the least permeability across the blood-brain barrier for the IONP with collagen formulation, suggesting a role as a magnetic resonance imaging contrast agent but limiting IONP passage across the blood-brain barrier. Further analysis of the data yielded several trends of note, with little correlation between permeability and fluid zeta potential, but a larger correlation between permeability and fluid particle size (with the smaller particle sizes having larger permeability). Such results lay the foundation for simple modification of iron oxide nanoparticle formulations to either promote or inhibit passage across the blood-brain barrier, and deserve further investigation for a wide range of applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.