ArticlePlant physiology2013
Multiple functions of Kip-related protein5 connect endoreduplication and cell elongation.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Carnivorous Nepenthes pitcher plants combine common developmental processes to make a complex epidermal trapping surface.Annals of botany · 2025Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
- Connecting high-resolution 3D chromatin maps with cell division and cell differentiation at the root apical meristem.Plant cell reports · 2024Article
- The SIAMESE family of cell-cycle inhibitors in the response of plants to environmental stresses.Frontiers in plant science · 2024Review
- Characterization of the soybean KRP gene family reveals a key role for GmKRP2a in root development.Frontiers in plant science · 2023Article
- Detection of epistasis interaction loci for fiber quality-related trait via 3VmrMLM in upland cotton.Frontiers in plant science · 2023Article
- CINCINNATA-Like TCP Transcription Factors in Cell Growth - An Expanding Portfolio.Frontiers in plant science · 2022Review
- Fruit size control by a zinc finger protein regulating pericarp cell size in tomato.Molecular horticulture · 2021Article
- Genome-Wide Association Analysis Reveals Loci and Candidate Genes Involved in Fiber Quality Traits Under Multiple Field Environments in Cotton (Frontiers in plant science · 2021Article
- Molecular networks regulating cell division during Arabidopsis leaf growth.Journal of experimental botany · 2020Review
- A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.Journal of experimental botany · 2020Article
- Organ-wide and ploidy-dependent regulation both contribute to cell-size determination: evidence from a computational model of tomato fruit.Journal of experimental botany · 2019Article
- Genetic and transcriptomic dissection of the fiber length trait from a cotton (Gossypium hirsutum L.) MAGIC population.BMC genomics · 2019Article
- Resequencing a core collection of upland cotton identifies genomic variation and loci influencing fiber quality and yield.Nature genetics · 2018Article
- Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule.PLoS genetics · 2018Article
- At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato.The Plant cell · 2018Article
- Cell cycle arrest in plants: what distinguishes quiescence, dormancy and differentiated G1?Annals of botany · 2017Review
- The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility.Genome biology · 2017Article
- Plant Cyclin-Dependent Kinase Inhibitors of the KRP Family: Potent Inhibitors of Root-Knot Nematode Feeding Sites in Plant Roots.Frontiers in plant science · 2017Review
- Transcriptomic Effects of the Cell Cycle Regulator LGO inFrontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite considerable progress in our knowledge regarding the cell cycle inhibitor of the Kip-related protein (KRP) family in plants, less is known about the coordination of endoreduplication and cell differentiation. In animals, the role of cyclin-dependent kinase (CDK) inhibitors as multifunctional factors coordinating cell cycle regulation and cell differentiation is well documented and involves not only the inhibition of CDK/cyclin complexes but also other mechanisms, among them the regulation of transcription. Interestingly, several plant KRPs have a punctuated distribution in the nucleus, suggesting that they are associated with heterochromatin. Here, one of these chromatin-bound KRPs, KRP5, has been studied in Arabidopsis (Arabidopsis thaliana). KRP5 is expressed in endoreduplicating cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive regulator of endoreduplication. This regulation relies on several mechanisms: in addition to its role in cyclin/CDK kinase inhibition previously described, chromatin immunoprecipitation sequencing data combined with transcript quantification provide evidence that KRP5 regulates the transcription of genes involved in cell wall organization. Furthermore, KRP5 overexpression increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related protein5 (atxr5) atxr6 double mutant, which is deficient for the deposition of heterochromatin marks. Hence, KRP5 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the expression of genes required for cell elongation.
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