ArticleOncology letters2013
Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway.Annals of medicine · 2024Article
- The Role of Body Mass Index (BMI) in Differentiated Thyroid Cancer: A Potential Prognostic Factor?Biomedicines · 2024Article
- Characterization of Thyroid Cancer among Hispanics in California, USA, from 2010 to 2020.Cancers · 2024Article
- The role of neck adipose tissue in lymph node metastasis of head and neck cancer.Frontiers in oncology · 2024Review
- Obesity and Thyroid Cancer Risk: An Update.International journal of environmental research and public health · 2022Review
- Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines.Journal of physiology and biochemistry · 2021Article
- Evaluation of allelic alterations in short tandem repeats in papillary thyroid cancer.Molecular genetics & genomic medicine · 2020Article
- Circulating adipokines and metabolic setting in differentiated thyroid cancer.Endocrine connections · 2019Article
- Cross-Talk between Inflammatory Mediators and the Epithelial Mesenchymal Transition Process in the Development of Thyroid Carcinoma.International journal of molecular sciences · 2019Review
- Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells.International journal of endocrinology · 2019Article
- Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women.Endocrine · 2019Review
- The potential role of leptin in tumor invasion and metastasis.Cytokine & growth factor reviews · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin and OBRs in 76 PTC samples using immunohistochemistry, and their associations with clinicopathological parameters were evaluated. The expression of OBRs was observed in the tumor cell membrane and/or cytoplasm, with a positive rate of 73.7% (56/76), while leptin was expressed in the tumor cell cytoplasm in 55 of 76 cases (72.4%). The expression of either protein was associated with greater tumor size (P=0.016 for leptin and P=0.002 for OBRs). In addition, the expression levels of leptin and OBRs were associated with each other. Neither leptin nor OBR expression levels were associated with other parameters, including age, body weight, postmenopausal state, multifocality and lymph node metastasis. These data suggest that the expression of leptin and/or OBRs in PTC is associated with tumor size and may be a potential target in PTC.
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