Trial reportThe journal of trauma and acute care surgery2013
Platelets are dominant contributors to hypercoagulability after injury.
Trial report in The journal of trauma and acute care surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02475187 (Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture
Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
- Multiplate and TEG platelet mapping in a population of severely injured trauma patients.Transfusion medicine (Oxford, England) · 2018Trial
- Effects of non-vitamin K antagonist oral anticoagulants on fibrin clot and whole blood clot formation, integrity and thrombolysis in patients with atrial fibrillation.Journal of thrombosis and thrombolysis · 2016Trial
- Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences.Journal of proteomics · 2015Trial
- Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.Shock (Augusta, Ga.) · 2014Trial
- Prothrombotic Tendency in the Shadow of Cancer: Hypercoagulability, Impaired Clot Contraction and Fibrinolysis in Colorectal Cancer and Gastric Cancer Patients Undergoing Chemotherapy.International journal of molecular sciences · 2026Article
- Hemostatic abnormalities after trauma resuscitation: challenges and strategies in caring for the critically injured patient.Annals of intensive care · 2025Review
- Evaluating risk factors of embolism in patients with cardiac myxoma: A systematic review and meta-analysis.American heart journal plus : cardiology research and practice · 2025Article
- Inflammatory markers in conventional vs. active robot-assisted total knee arthroplasty and other variables.BMC musculoskeletal disorders · 2025Article
- Thromboelastography in COVID-19 patients: An observational study in the South African context.African journal of laboratory medicine · 2025Article
- Article
- Citrate Phosphate Dextrose Alters Coagulation Dynamics Ex Vivo.The Journal of surgical research · 2023Article
- Addition of aspirin to venous thromboembolism chemoprophylaxis safely decreases venous thromboembolism rates in trauma patients.Trauma surgery & acute care open · 2023Article
- Review
- Observational
- Serial Thromboelastography and the Development of Venous Thromboembolism in Critically Ill Patients With COVID-19.Critical care explorations · 2022Article
- Thromboelastography Parameters and Platelet Count on Admission to the ICU and the Development of Venous Thromboembolism in Patients With Coronavirus Disease 2019.Critical care explorations · 2021Article
- Complex and prolonged hypercoagulability in coronavirus disease 2019 intensive care unit patients: A thromboelastographic study.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2021Article
- Admission thrombelastography does not guide dose adjustment of enoxaparin in trauma patients.Surgery open science · 2020Article
- Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury.Frontiers in immunology · 2020Article
- Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.Journal of thrombosis and haemostasis : JTH · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVenous thromboembolic (VTE) disease has a high incidence following trauma, but debate remains regarding optimal prophylaxis. Thrombelastography (TEG) has been suggested to be optimal in guiding prophylaxis. Thus, we designed a phase II randomized controlled trial to test the hypothesis that TEG-guided prophylaxis with escalating low-molecular weight heparin (LMWH), followed by antiplatelet therapy would reduce VTE incidence.
methodsSurgical intensive care unit trauma patients (n = 50) were randomized to receive 5,000 IU of LMWH daily (control) or to TEG-guided prophylaxis, up to 5,000 IU twice daily with the addition of aspirin, and were followed up for 5 days. In vitro studies were also conducted in which apheresis platelets were added to blood from healthy volunteers (n = 10).
resultsControl (n = 25) and TEG-guided prophylaxis (n = 25) groups were similar in age, body mass index, Injury Severity Score, and male sex. Fibrinogen levels and platelet counts did not differ, and increased LMWH did not affect clot strength between the control and study groups. The correlation of clot strength (G value) with fibrinogen was stronger on Days 1 and 2 but was superseded by platelet count on Days 3, 4, and 5. There was also a trend in increased platelet contribution to clot strength in patients receiving increased LMWH. In vitro studies demonstrated apheresis platelets significantly increased clot strength (7.19 ± 0.35 to 10.34 ± 0.29), as well as thrombus generation (713.86 ± 12.19 to 814.42 ± 7.97) and fibrin production (274.03 ± 15.82 to 427.95 ± 16.58).
conclusionIncreased LMWH seemed to increase platelet contribution to clot strength early in the study but failed to affect the overall rise clot strength. Over time, platelet count had the strongest correlation with clot strength, and in vitro studies demonstrated that increased platelet counts increase fibrin production and thrombus generation. In sum, these data suggest an important role for antiplatelet therapy in VTE prophylaxis following trauma, particularly after 48 hours. LEVEL OF EVIDENCE: Therapeutic study, level III.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.